Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Potentiation of Local Anesthetic Activity of Calotropis Gigantea Latex with Epinephrine and pH in Guinea Pig


Affiliations
1 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
     

   Subscribe/Renew Journal


The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.

Keywords

Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Rastogi Ram P and Mehrotra BM. 1991 In : Compendium of Indian Medicinal Plants. Pbl. Central Drug Research Institute, Lucknow and Publications & Information Directorate, N. Delhi, 70-73.

  • Oudhia P, Kolhe SS and Tripathi RS. 1998a. In: Abstract. III International Congress on Allelopathy in Ecological Agriculture and Forestry, UAS, Dharwad, India 18-21.

  • Caius JF. 1986. The medicinal and poisonous plants of India. Scientific Publ, Jodhpur, India.

  • Das BB. 1996. Rasraj Mahodadhi. Khemraj Shri Krishnadas Prakashan, Bombay.

  • Agharkar SP. 1991. Medicinal plants of Bombay presidency. Scientific Publ, India. 48-49.

  • Ghosh NC 1988. Comparative Materia Medica. Hannemann Publ. Co. Pvt. Ltd. Calcutta, India.

  • Singh U, Wadhwani AM and Johri BM. 1996. Dictionary of Economic Plants of India. Indian Council of Agricultural Research, New Delhi. 38-39.

  • Oudhia P and Tripathi RS. 1998. Proc. National Conference on Health Care and Development of Herbal Medicines, IGAU, Raipur, India 29-30,71-78.

  • Oudhia P, Kolhe SS and Tripathi RS. 1997. Legume Res. 20(2),133-136.

  • Herbal monograph, Himalaya herbal healthcare, India.

  • Grieve M,A modern herbal.www.botanical.com.

  • Ramanathan T, Evaluation of local anesthetic activity from Calotropis procera in Euphylyctus hexadactylus. Plant Archives,2008,8(2): 995-997.

  • Rajasekhar KK, Shankarananth V, Venkateswarlu M, Nirosha M, Thushara bindhu D and Narender reddy K. Local anaesthetic activity of Tabernaemontana coronaria latex in frog and Guinea pig. Journal of Pharmacy Research November 2009 , 2(11),1691- 1693.

  • Rajasekhar KK, Shankarananth V, Rajagowtham M, Gowtham kumar B, Thejnayan B and Pavankumar M. Local anaesthetic activity of Calotropis gigantea latex in frog and Guinea pig. Research Journal of Pharmacology and Pharmacodynamics, March-April 2010, 2(2), In Press.

  • Rajendra Prasad Y, Rajasekhar KK, Shankarananth V, Tejaswi E, Prathyusha RJ, and Sunandhana T. Potentiation of Local anaesthetic activity of Calotropis procera latex with epinephrine and pH in Guinea pig. International Journal of Pharma Recent Research December 2009 , 1(1),54-58.

  • Rajasekhar KK , Shankarananth V, Dinesh kumar P, Kartheek Y,Harinatha reddy P, and Mukesh O. Effect of epinephrine and pH on Local anaesthetic activity of Tabernaemontana coronaria latex in Guinea pig. Journal of Pharmacy Research December 2009, 2 (12), 1886-1888.

  • Bernards CM and Kopacz DJ, Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans. Anesthesiology, 1999,91: 962-968.

  • Hille B. Theories of Anesthesia, General perturbations versus specific receptors. Mechanisms of Anesthesia,Vol.2, Progress in Anesthesiology, Raven press: Newyork,1980, 551-565.

  • Indian Pharmacopoeia, Ministry of Health and Family Welfare, Government of India, Controller of Publications, Delhi, Vol- II,1996,A-144.

  • Kulkarni SK. Handbook of Experimental Pharmacology, Local anesthetics, 3rd edition, 1999, 152.


Abstract Views: 274

PDF Views: 2




  • Potentiation of Local Anesthetic Activity of Calotropis Gigantea Latex with Epinephrine and pH in Guinea Pig

Abstract Views: 274  |  PDF Views: 2

Authors

K. K. Rajasekhar
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
V. Shankarananth
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
C. Sreelakshmi
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
A. Sushmitha
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
S. Ch. Moulali
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India
V. Swetha Reddy
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., India

Abstract


The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.

Keywords


Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.

References