Research Journal of Pharmacology and Pharmacodynamics

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Effect of Root Extracts and Isolated Compounds of Xanthium strumarium L. on Ehrlich Ascites Carcinoma in Mice


Affiliations
1 Department of Pharmacology, Dayanandsagar College of Pharmacy, Shavige Malleshwara Hills, Kumarswamy Layout, Banglore, Karnataka, 560078, India
2 Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, Karnataka, India
3 Department of Biotechnology, Kuvempu University, Shimoga, Karnataka, India
     

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A mixture of Xanthine, Xanthone and Xanthosine isolated from the ischolar_main of Xanthium strumarium L exhibited antitumor activities against Ehrlich Ascites Carcinoma in Swiss albino mice. Animals were pre-treated orally with the extract at a dose of 200mg/kg, 25 and 50mg/kg body weight for isolated compounds of chloroform extract and then after 24hrs EAC (at a dose of 2×106 cells/mouse) administration and following an 18hr fasting; mice were sacrificed for studying of antitumor activity. The decrement of tumor volume, packed cell volume and viable cell count were observed in both lignans and isolated compounds of chloroform extract treated animals and compared with only EAC tumor bearing mice. Treatment with test compounds increased the survival time and normal peritoneal cell count. Hematological parameters, PCV which were altered by tumor volume inoculation, were restored considerably. Thus, this study was an attempt to evaluate the preventive and curative role of X. strumarium lignans in tumor bearing mice.

Keywords

Ehrlich Ascites Carcinoma, Xanthium strumarium, Lignans, Xanthone, Xanthine and Xanthosine.
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  • Kapadia GJ, Azuuine MA, Takayasu J, Konoshima T, Takasaki M, Nishino H. Inhibition of Epistein-Barr Virus early antigen activation promoted by 12-O-tetrdecnopylphorbol-130acetate by the non-steroidal anti-inflammatory drugs. Cancer Letter 2000; 161: 221-229.

  • Ho CT, Osawa T Huang MT, Rosen RT(eds). Food Phytochemicals for Cancer Prevention II Teas, Spices, and Herbs. ACS Symposium 547. Washington DC, American Cancer Society 1994.

  • Huang MT, Osawa T, Ho CT, Rosen RT (eds). Food Phytochemicals for Cancer Prevention I Fruits and Vegitables ACS Symposium 547. Washigton DC.

  • Richardson MA, Sander T, Palmer JL, GresisingerA, Singletary SE. J.Clin.Oncol 2000; 18:2505-2514.Agharkar, S P. Medicinal plants of Bombay presidency. Pbl. Scientific Publishers, Jodhpur, (India) 1991: 230.

  • Badami, S, Mahesh KG and Suresh B. Antioxidant activity of the ethanol extract of striorobanchioides. J Ethnopharmaocol .2003; 85:227-229.

  • Gupta M, Mazumder UK, Rath N, Mukhopadhyay D K. Antitumor activity of methanol extract of Cassia fistula L. seed against Ehrlich ascites carcinoma. J Ethanopharmacol 2000; 72:151-156.

  • Mazumder UK, Gupta M, Maiti S, Mukherjee M. Antitumor activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice. Indian J Expt Biol. 1997; 35: 473-477.

  • Wintrobe MM, Lee GR, Boggs DR, Bithel TC, Athens JW, Foerester J. Clinical Heamtology. 5th ed. Philadelphia: 1961: 320.

  • Wintrobe MM, Lee GR, Boggs BR, Bithel TC, Athens JW, Foerester. Clinical Hematology 5th ed. Philadelphia; 1961:326.

  • Dacie JV, Lewis SM. Practical hematology, 2nd ed. London: J and A Churchill, 1958:38-48.

  • Ohkawa H, Ohishi N, Yaki K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-8.

  • Clarkson BD and Burchenal JH. Preliminary screening of antineoplastic drugs. Prog Clin Cancer 1965; 1:625-629.

  • Oberling, C, Guerin, M. The role of viruses in the production of cancer, Advances in Cancer Research II, Academic Press, New York 1954: 406-410.

  • Price, VE and Greenfield, RE. Anaemia in cancer. Adv Cancer Res., 1958 5:199-200.

  • Fenninger, LD and Mider, GB. Energy and nitrogern metabolism in cancer. Adv Cancer Res 1954 : 2:229-253.

  • Teitz, NW Enzymes in text book of clinical chemistry, Teitz NW (EDs): Philidephia; WB Saunders Co 1986 :579-5847.


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  • Effect of Root Extracts and Isolated Compounds of Xanthium strumarium L. on Ehrlich Ascites Carcinoma in Mice

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Authors

N. B. Sridharamurthy
Department of Pharmacology, Dayanandsagar College of Pharmacy, Shavige Malleshwara Hills, Kumarswamy Layout, Banglore, Karnataka, 560078, India
R. Yogananda
Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, Karnataka, India
Riyaz Mahamood
Department of Biotechnology, Kuvempu University, Shimoga, Karnataka, India

Abstract


A mixture of Xanthine, Xanthone and Xanthosine isolated from the ischolar_main of Xanthium strumarium L exhibited antitumor activities against Ehrlich Ascites Carcinoma in Swiss albino mice. Animals were pre-treated orally with the extract at a dose of 200mg/kg, 25 and 50mg/kg body weight for isolated compounds of chloroform extract and then after 24hrs EAC (at a dose of 2×106 cells/mouse) administration and following an 18hr fasting; mice were sacrificed for studying of antitumor activity. The decrement of tumor volume, packed cell volume and viable cell count were observed in both lignans and isolated compounds of chloroform extract treated animals and compared with only EAC tumor bearing mice. Treatment with test compounds increased the survival time and normal peritoneal cell count. Hematological parameters, PCV which were altered by tumor volume inoculation, were restored considerably. Thus, this study was an attempt to evaluate the preventive and curative role of X. strumarium lignans in tumor bearing mice.

Keywords


Ehrlich Ascites Carcinoma, Xanthium strumarium, Lignans, Xanthone, Xanthine and Xanthosine.

References