Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Antiulcer Activity of Coccinia grandis Leaves


Affiliations
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, India
2 MAM College of Pharmacy, Narsaraopet, Guntur, India
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
4 Dept of Biochemistry S.V. University, Tirupati.517-501, India
5 Sri Padmavathi School of Pharmacy, Tirupati, India
     

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The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords

Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.
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  • Evaluation of Antiulcer Activity of Coccinia grandis Leaves

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Authors

C. Girish
Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, India
S. Vineela
MAM College of Pharmacy, Narsaraopet, Guntur, India
Y. Narasimha Reddy
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
O. V. S. Reddy
Dept of Biochemistry S.V. University, Tirupati.517-501, India
K. K. Rajasekhar
Sri Padmavathi School of Pharmacy, Tirupati, India
V. Shankarananth
Sri Padmavathi School of Pharmacy, Tirupati, India

Abstract


The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords


Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.

References