Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Antiulcer Activity of Coccinia grandis Leaves


Affiliations
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, India
2 MAM College of Pharmacy, Narsaraopet, Guntur, India
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
4 Dept of Biochemistry S.V. University, Tirupati.517-501, India
5 Sri Padmavathi School of Pharmacy, Tirupati, India
     

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The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords

Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.
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  • Falk GW, Cecil Essentials of Medicine 5th Edn., W.B.Saunders Company, Edinburgh. 2001: 334-343.

  • Wallace JL. 1992. Non-steroidal anti-inflammatory drug gastropathy and cytoprotection–pathogenesis and mechanisms reexamined. Scand J Gastroenterol 27: S192, 3-8.

  • Mcquaid KR., Current Medical Diagnosis and Treatment. 41st Edn. Lange Medical Books/McGraw Hill Company, New York. 2002:616-621.

  • Ariyoshi L, Toshiharu, Sugimura F, Abe M, Matsuo Y, Honda T. 1986. Recurrence during maintenance therapy with histamine H2 receptor antagonist in cases of gastric ulcer. Nithon Univ J Med 28: 69-74.

  • Clouatre D, Rosenbaum M 1994. The Diet and Health benefits of HCA (hydroxycitric acid), Keats publishing: New York, 31-32.

  • Borrelli F, Izzo AA, The Plant Kingdom as a Source of Anti- Ulcer Remedies. Phytotherapy Research. 2000; 14: 581-591.

  • Warrier PK., Nambiar VPK, Ramankutty C., Indian Medicinal Plants. Orient Longman, Madras. 1994; Vol.2: 133-137.

  • Ecobichon DJ., The basis of toxicity testing CRS Press, New York. 1997; 43-49.

  • Shay H, Komarov SA, Fele SS, Meranze D, Gruenstein H, Siplet H. A Simple method for uniform production of gastric ulceration in rat, Gastroenterol, 1945, 5, 43-61.

  • Mahmod AA. Int J Mol Adv Sci, 2005, 1, 225.

  • Hikino H, recent research on oriental medicinal plants, in economic and medicinal plant research, edited by H Wagner, H Hikino & N R Farnsworth (Academic press, London) 1985,53.

  • Szabo, S., Szlenji, S. 1987. Cytoprotection in gastrointestinal pharmacology. Trends Pharmacl. Sci.8,149-54.

  • Tan PV, Dimo T. and Dongo E (2000). Effects of methanol cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats. J. ethnopharmacol. 73: 415-421.

  • Yamamoto, K., Kakegawa, H., Matsumoto, H., Sudo, T. and Satoh, T. (1992). Gastric cytoprotective antiulcerogenicactions of hydroxychalcones in rats. Planta Medica. 58: 389-393.

  • Dhuley JN. Protective effect of Rhinax, a herbal formation against physical and chemical factors induced gastric and duodenal ulcers in rats. Indian J Pharmacol 1999, 31, 128-32.

  • Soll AH. Pathogenesis of peptic ulcers and implication for therapy. New Eng J Med 1990, 322,909- 16.

  • Surendra S. Evaluation of gastric antiulcer activity of fixed oil of tulsi and possible mechanism. Indian J Exp Biol, 1999, 36(3),253-57.

  • Goel RK, Bhattacharya SK. Gastro duodenal mucosal defense and mucosal protective agents. Indian J Expl Biol 1991; 29:701-14.


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  • Evaluation of Antiulcer Activity of Coccinia grandis Leaves

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Authors

C. Girish
Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, India
S. Vineela
MAM College of Pharmacy, Narsaraopet, Guntur, India
Y. Narasimha Reddy
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
O. V. S. Reddy
Dept of Biochemistry S.V. University, Tirupati.517-501, India
K. K. Rajasekhar
Sri Padmavathi School of Pharmacy, Tirupati, India
V. Shankarananth
Sri Padmavathi School of Pharmacy, Tirupati, India

Abstract


The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords


Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.

References