Research Journal of Pharmacology and Pharmacodynamics

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Pharmacological Evaluation of Oxalis corniculata Linn for Anthelmintic Activity


Affiliations
1 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravranagar, Maharashtra, 413736, India
2 Dept. of Pharmaceutical Chemistry, MAEER, Maharashtra Institute of Pharmacy, Pune Maharashtra, India
3 Department of Pharmaceutical Chemistry, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, India
     

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The present study aimed at the in-vitro comparative study of anthelmintic activity of petroleum ether, ethyl acetate and methanol extracts of whole plant of Oxalis corniculata Linn. using Eisenia foetida at three different concentrations (100, 200, and 400 mg/ml) respectively. The study involved the determination of time of paralysis (P) and time of death (D) of the worms. At the concentration of 400 mg/ml all the extracts showed very significant activities as compared to the standard drug levamisole (0.55 mg/ml). Each extract with the dose 100, 200, and 400 mg/ml, produced dose-dependent paralysis ranging from loss of motility to loss of response to external stimuli, which gradually progressed to death. In case of methanol extract which was found to be most potent, the time of paralysis and death time was observed as 11.33 and 41.33 min, respectively. In conclusion, the use of O. corniculata as possible anthelmintic is explored and further studies are suggested to isolate the active principles responsible for the activity.

Keywords

Anthelmintic, Eisenia foetida, Oxalis corniculata Linn.
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  • Pharmacological Evaluation of Oxalis corniculata Linn for Anthelmintic Activity

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Authors

Santosh B. Dighe
Department of Pharmacology, Pravara Rural College of Pharmacy, Pravranagar, Maharashtra, 413736, India
B. S. Kuchekar
Dept. of Pharmaceutical Chemistry, MAEER, Maharashtra Institute of Pharmacy, Pune Maharashtra, India
Sagar B. Wankhede
Department of Pharmaceutical Chemistry, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, India

Abstract


The present study aimed at the in-vitro comparative study of anthelmintic activity of petroleum ether, ethyl acetate and methanol extracts of whole plant of Oxalis corniculata Linn. using Eisenia foetida at three different concentrations (100, 200, and 400 mg/ml) respectively. The study involved the determination of time of paralysis (P) and time of death (D) of the worms. At the concentration of 400 mg/ml all the extracts showed very significant activities as compared to the standard drug levamisole (0.55 mg/ml). Each extract with the dose 100, 200, and 400 mg/ml, produced dose-dependent paralysis ranging from loss of motility to loss of response to external stimuli, which gradually progressed to death. In case of methanol extract which was found to be most potent, the time of paralysis and death time was observed as 11.33 and 41.33 min, respectively. In conclusion, the use of O. corniculata as possible anthelmintic is explored and further studies are suggested to isolate the active principles responsible for the activity.

Keywords


Anthelmintic, Eisenia foetida, Oxalis corniculata Linn.

References