Research Journal of Pharmacology and Pharmacodynamics

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Pharmacological Evaluation of Antiasthmatic Activity of Tamarindus indica Seed


Affiliations
1 Department of Pharmacology, R. V. S. College of Pharmaceutical Science, 242, Trichy Road Sulur, Coimbatore-641 402., India
2 Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India
     

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Practical experience and several modern research studies have shown that therapy using plant is better than using synthetic chemicals. According to ayurvedic folklore the Tamarindus indica Linn was mentioned for several ailments including asthma (kirtikar et al; 2001) the present study was planned to know the anti asthmatic activity of methanolic extract of this plant at different stages or different types of asthma using various evaluation models like, isolated goat tracheal chain preparation, bronchial hyperactivity, clonidine induced catalepsy in guinea pig, mast cell degranulation, milk induced leucocytosis in mice, milk induced eosinophilia in mice, passive paw anaphylaxis, and its activities such as bronchodilating, antihistaminic, anti inflammatory , anti allergic, mast cell stabilizing and adaptogenic activities were confirmed presenting the scope of plant for further studies. The data was analyzed by student't' test or one way ANOVA followed by Dunnett test. P≤0.05 was considered as significant.

Keywords

Tamarindus Indica Linn., Catalepsy, Leukocytosis, Anaphylaxis, Degranulation.
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  • Pharmacological Evaluation of Antiasthmatic Activity of Tamarindus indica Seed

Abstract Views: 301  |  PDF Views: 1

Authors

R. Suresh
Department of Pharmacology, R. V. S. College of Pharmaceutical Science, 242, Trichy Road Sulur, Coimbatore-641 402., India
Ganesh Pandhari Mhaske
Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India
Nehru Sai Suresh Chalichem
Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India
Ashok Kumar Javvadi
Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India
D. Benito Johnson
Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India
R. Venkatanarayanan
Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, India

Abstract


Practical experience and several modern research studies have shown that therapy using plant is better than using synthetic chemicals. According to ayurvedic folklore the Tamarindus indica Linn was mentioned for several ailments including asthma (kirtikar et al; 2001) the present study was planned to know the anti asthmatic activity of methanolic extract of this plant at different stages or different types of asthma using various evaluation models like, isolated goat tracheal chain preparation, bronchial hyperactivity, clonidine induced catalepsy in guinea pig, mast cell degranulation, milk induced leucocytosis in mice, milk induced eosinophilia in mice, passive paw anaphylaxis, and its activities such as bronchodilating, antihistaminic, anti inflammatory , anti allergic, mast cell stabilizing and adaptogenic activities were confirmed presenting the scope of plant for further studies. The data was analyzed by student't' test or one way ANOVA followed by Dunnett test. P≤0.05 was considered as significant.

Keywords


Tamarindus Indica Linn., Catalepsy, Leukocytosis, Anaphylaxis, Degranulation.

References