Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Diuretic Activity of whole Plant Extract of Leptadenia reticulata


Affiliations
1 Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, Andhra Pradesh, India
2 Srikrupa Institute of Pharmaceutical Sciences, Siddipet. Andhra Pradesh, India
3 PGP College of Pharmaceutical Science & Research Institute, Namakkal, India
     

   Subscribe/Renew Journal


The present study was undertaken to investigate the diuretic effect of aqueous and ethanolic extract of the Whole plant of Leptadenia reticulata in normal rats. Aqueous and ethanolic extracts of whole plants of Leptadenia reticulata were administered to experimental rats orally at doses of 100mg/kg p.o. Furosemide (100 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Urine volume was significantly increased by both aqueous and ethanolic extract in comparison to the control group but this effect was less than furosemide. Significant increase in renal clearance of sodium, potassium and chloride ions was observed in treated and standard groups.

Keywords

Diuretic Activity, Furosemide, Leptadenia reticulata, Aqueous and Ethanol.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Parekh, J. and S.Chanda, 2007. In vitro antibacterial activity of the crude methanol extract of Wood fordia fruticosa kurz. flower (lythraceae). Brazilian J. Microbiol., 38: 204-207.

  • Agunu ,A., Abdurahman, E.M., Andrew, G.O., Muhammed Z. Diuretic activity of the stem-bark extracts of Steganotaenia araliaceahoehst. J. Ethnopharmcol 2005,96,471-5.

  • Devi P, Meera R, Muthumani P, Chilakalapudi R., Thota V.K., Duddu. V.D. Murthy, Jeyasundari K.. International Journal of Pharmaceutical & Biological Archives 2010, 1(4), 331-334.

  • Satyavati,G.V., A.K.Gupta, N.Tandon and S.D.Seth, 1987. Medicinal plant of india. Vol. 2, Indian council of medicinal research , New delhi , India.

  • Khare,CC.P., 2004. Encyclopedia of indian medicinal plants.Springer,New york, USA.

  • Gupta, A.K., N. Tandon and M.Sharma , 2005.Quality standards of indian medicinal plants. Vol. 2, Oxford university press , New delhi , India , ISBN : 0009727213 , pp : 301.

  • Gupta,R.C., 1997. Botanical identity of Jivanti - the Ayurvedic rejuvenant par excellance.Applied Bot., 17 : 49-63.

  • Aarwal, S.L., B.S. Deshmankar, S.C.L. Verma and S.P. Saxena, 1960.Studies on Leptadenia reticulata, part I. Pharmacological actions of aqueous extract. Ind .J.Med.Res., 48: 457-464.

  • Hakim, R.A., 1964. A preliminary report on the use of malkanguni with other indigenous drugs in the treatment of depression. Ind . J . Psychiatry, 6: 142-146.

  • Achari, K. And R. Sinha, 1966. Treatment of threatened and recurrent abortions (A clinical study of 62 cases with Leptaden). Patna J. Med., 30: 1-3.

  • Marya, S.K.S., P.Garg, A.K.Gupta and V.K.Sharma, 1995. Role of speman in bening prostatic hperplasia. Surg. J. North india, 11 : 126-131.

  • Padmalatha, K., B.V. Venkataraman and R. Roopa, 2002. Antianaphylactic effect of DLH – 3041 (polyherbal formulation) on rat mesentric mast cell degranulation. Ind. J. Pharmacol., 34: 119-112.

  • Sathiyanarayana, L., A. Sinnathambi and N. Chidambaranathan, 2007. Anticarcinogenic activity of Leptadenia reticulata against Daltons ascitic lymphoma . J . Pharmacol. Therap., 6 : 133-135.

  • Rani, S., R. Manavalan, D. Kilimozhi and K. Balamurugan, 2009. Preliminary study on the anti-implantation activity of Leptadenia reticulata in female rats. Int. J. Pharm. Tech. Res., 1: 1403-1405.

  • Vaghasiya, Y . and S. Chanda, 2007 . Screening of methanol and acetone extracts of fourteen indian medicinal plants for antimicriobial activity . Turk. J . Biol., 31: 243-248.

  • Vogel H.G. "Drug Discovery and Evaluation", Experimental evaluation of diuretics;2nd edition, 2002, p. 323.

  • Lipschitz W.L, Haddian Z, Kepscar A. J Pharmacol Exp Ther., 1943, 79, 110.

  • Amritage , P .Eds., In; Stastical Methods in Medical Research, Blackwell Scientific Publications,London 1971 , 217 .

  • Hoeland, R.D and Mycek, M.J., Lippincott’s illustrated Reviews: Pharmacology, Lippincott Willams and Wilkins, Philadelphia, 2000, 157-58; 240-241.

  • Guyton, A.C. Blood pressure control special role of the kidneys and body fluids. Science 1991, 252, 1813-6.


Abstract Views: 272

PDF Views: 0




  • Diuretic Activity of whole Plant Extract of Leptadenia reticulata

Abstract Views: 272  |  PDF Views: 0

Authors

S. Mohanraj
Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, Andhra Pradesh, India
C. Santhoshkumar
Srikrupa Institute of Pharmaceutical Sciences, Siddipet. Andhra Pradesh, India
A. Chandran
PGP College of Pharmaceutical Science & Research Institute, Namakkal, India

Abstract


The present study was undertaken to investigate the diuretic effect of aqueous and ethanolic extract of the Whole plant of Leptadenia reticulata in normal rats. Aqueous and ethanolic extracts of whole plants of Leptadenia reticulata were administered to experimental rats orally at doses of 100mg/kg p.o. Furosemide (100 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Urine volume was significantly increased by both aqueous and ethanolic extract in comparison to the control group but this effect was less than furosemide. Significant increase in renal clearance of sodium, potassium and chloride ions was observed in treated and standard groups.

Keywords


Diuretic Activity, Furosemide, Leptadenia reticulata, Aqueous and Ethanol.

References