Research Journal of Pharmacology and Pharmacodynamics

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Anti-Arthritic and Anti-Inflammatory Effect of Cetylmyristeolate against Freund's Adjuvant Induced Arthritis Model


Affiliations
1 Division of Pharmacology, RMMC and H, Annamalai University, Annamalai Nagar, Chidambaram, India
2 Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, India
     

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To evaluate the effect of Cetylmyristeolate (CMO) in Freund's complete adjuvant induced arthritis in rats. The experimental study was evaluated on male and female Wister rats weighing (150-200gms). 0.5ml of Freund's complete adjuvant (FCA) in the left tibiotarsal joint (IA) was injected to induce arthritis, CMO-500mg;1g and CMO100mg+MSM200mg + glucosamine 500mg/day for 21 days were given. Paw edema by plesthysmometer and arthritic index were studied, the results showed marked reduction of arthritic and inflammatory effect by CMO500mg/day and 1gm/day as well as the combination of 100mg/day + glucosamine 500mg and MSM 200mg/day. Percentage inhibition of paw volume edema was statistically significant and reductions in the arthritic index scores were comparable with reference standard drug dexamethasone. From the results of this study, it was concluded that CMO as well as the combinations produced a statistically significant effect in reducing carrageenan induced arthritis in rats.

Keywords

Cetyl Myristoleate (CMO), Glucosamine Sulphate, Methyl Sulfonyl Methane (MSM), Dexamethasone, Arthritis.
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  • Anti-Arthritic and Anti-Inflammatory Effect of Cetylmyristeolate against Freund's Adjuvant Induced Arthritis Model

Abstract Views: 253  |  PDF Views: 2

Authors

M. K. Kayalvizhi
Division of Pharmacology, RMMC and H, Annamalai University, Annamalai Nagar, Chidambaram, India
Vanitha Samuel
Division of Pharmacology, RMMC and H, Annamalai University, Annamalai Nagar, Chidambaram, India
P. Nirmala
Division of Pharmacology, RMMC and H, Annamalai University, Annamalai Nagar, Chidambaram, India
K. Balamurugan
Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, India

Abstract


To evaluate the effect of Cetylmyristeolate (CMO) in Freund's complete adjuvant induced arthritis in rats. The experimental study was evaluated on male and female Wister rats weighing (150-200gms). 0.5ml of Freund's complete adjuvant (FCA) in the left tibiotarsal joint (IA) was injected to induce arthritis, CMO-500mg;1g and CMO100mg+MSM200mg + glucosamine 500mg/day for 21 days were given. Paw edema by plesthysmometer and arthritic index were studied, the results showed marked reduction of arthritic and inflammatory effect by CMO500mg/day and 1gm/day as well as the combination of 100mg/day + glucosamine 500mg and MSM 200mg/day. Percentage inhibition of paw volume edema was statistically significant and reductions in the arthritic index scores were comparable with reference standard drug dexamethasone. From the results of this study, it was concluded that CMO as well as the combinations produced a statistically significant effect in reducing carrageenan induced arthritis in rats.

Keywords


Cetyl Myristoleate (CMO), Glucosamine Sulphate, Methyl Sulfonyl Methane (MSM), Dexamethasone, Arthritis.

References