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Antibiotics Induced Adverse Drug Reaction Monitoring in a Teaching Hospital in Chhattisgarh
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Aims- The Aims of this study were:
(a) To evaluate antibiotic exposure in inpatients in medicine departments of CIMS hospital.
(b) To determine the frequency of medication-related events;
(c) To characterize the types of ADR observed.
Material and Methods- A prospective, reporting study was conducted over a period of 6 months of inpatient admissions in the medicine departments of a teaching government hospital. The data of all inpatients undergoing antibiotic treatment were collected by our trained team and validated by an expert panel. Data were recorded on pre-formatted forms.
Results- Of the total of 1600 patient, analyzed 1300 adults (46%male 54% female) 300 children (50% male, 50% female). ceftriaxone (36%) was the most widely used antibiotics, cefotaxime 25%), inj ampicillin (16%) ofloxacin 10% amikacin 6%, gentamicin 6%, ciprofloxacin 5%, piperacilline+toza 2%. Out of 1600 patient, Adverse drug reaction were reported in 66 patient Drug cefotaxime developed leucopenia 7 days after therapy.
Drug ofloxacin developed life threatening complications (rashes, urticaria, perspiration) in 12 patients, later 10 patient detoriorated with shock and non recordable bp/pulse. Shifted to emergency ward.
After ciplox 10 adult patient and 2children developed skin rashes and urticaria along with gastro enteric disease. Amikacin given resulted after 3 days into renal changes and Later after 3 days resulted in raised urea and creatinine. Same adverse effect was seen with 3 patient with gentamicin. Piperacillin and Toza resulted with life threatening reaction i.e. angio neurotic edema and hypertension.
Conclusions- Hospital based monitoring is a good method with which to detect known and unknown links between drug exposure and ADRs. The clinicians should make an attempt for early detection and be vigilant about safety profile monitoring of the prescribed medications.
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