Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Potential of Carica papaya Against Gentamicin Induced Nephrotoxic Rats


Affiliations
1 PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Mannargudi-614001, Tamil Nadu, India
     

   Subscribe/Renew Journal


The present study was desined to evaluate the nephroprotective effect of ethanolic extracts of seeds of Carica papaya against gentamicin induced nephrotoxicity in albino rats. Oral administration of gentamicin (5mg/100g body weight/day) shows the significantly reduction in serum urea, uric acid, creatinine and protein, level were significantly decreased when compared to the control rats. Ethanolic extracts of seeds of Carica papaya administration (40 mg/kg b. wt/day) brought about the significant changes in biochemical parameters. The present work indicates that the Carica papaya extracts has showed their protective role against gentamicin induced nephrotoxicity and its more effective in preventing kidney damage that treating it.

Keywords

Nephrotoxicity, Renal Markers, Gentamicin, Carica papaya.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ali BH. Gentamicin nephrotoxicity in human and animals some recent research. General Pharamacology. 26; 2003: 1477-1487.

  • Anibijuwon II, and Vdeze AO. Antimicrobial activity of Carica papaya (Paw Paw leaf on some pathogenic organism of clinical origin from south-western Nigeria. Ethanobotanicial Leaflets.13; 2009: 850-864.

  • Anthony seaton, Anthony seaton, and Oouglas seaton, A. Gordeleitch Crofton and Douglas Respiratory disease. 1(1); 2000: 214.

  • Bennet WW. Mechanisms of aminoglycoside nephrotoxicity. Clin. Exp. Pharmacy., 16; 1989:1-6.

  • Bord J and Sirota JH. Journal of Clinical Investigation. 27; 1948:645.

  • Caraway WT. Standard methods of clinical chemistry. American Journal of Clinical Pathology. 25; 1963:480.

  • Dawkins G, Hewitt H, Wint Y, Obiefuna PC, and Wint B. Antibacterial effect of Carcia papaya fruit on common would organisms. J. West Indian med, 52(4); 2003: 290-292.

  • Eisenberg, J.M., Koffer, H., Glick, H.A., Connell, M.L., Lossle, Talbot, G.O.H., Nephtotoxicity associated with aminoglycoside Ann. Inter. Med. 1987, 107:900-909.

  • Giordani R, Siepaio M, Moulin-Traffort, J, and Regli, P. Antifungal action of Carica papaya latex:isolation of fungal ell wall hydrolyzing enzymes. Mycoses. 34 (11); 1991:469-477.

  • Harborne JB (1973). Phytochemical methods, London. Chapman and Hall, Ltd. 49-188.

  • John Bernard Henry. Clinical diagnosis and management by laboratory methods. Therapeutic drug monitoring . 1996: 394.

  • Kapoor M, Garg SK, Mathur VS. Anthiovulatory activity of five indigenous plants in rabbits. Indian J. Med., Res., 62(8); 1974: 1225-1227.

  • Krishna KL, Paridhavi M, and Patel A. A review nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn-Natural protect Radiance). 7(4); 2008:364-373.

  • Lohiya NKM, Kothari LK, Manivannan B, Mishrap K, Pathak N. Human sperm immobilization effect of Carica papaya seed extracts:an in vitro study. Asian J. Androl., 2(2); 2000: 103-109.

  • Natelson S, Scott ML, and Beffa C. Microtechniques of clinical chemistry for the Soutine laboratory. J. Chem. Path., 21; 1995:480.

  • Oloyede OL. Chemical profile of unripe of Carica papaya. Pakistan Journal of Nutrition. 4(6); 2005: 379-381.

  • Pedraza-Claverri, J, Maldonado PD, Mdina-Campos ON. Garlic amerliorates gentamicin nephrotoxicity:relation to antioxidant enzymes. Free radic Biol. Med., 29; 2000:602-611.

  • Rajkapoor B, Jayakar B, Kavimani S, Murugesh N. Effect of dried fruits of Carica papaya linn on hepatotoxicity. Biol Pharm Bull., 25(12); 2002:1645-1646.

  • Safirstein R, Wiston J, Goldstein M, Moel D, Dikman S, and Guttenplan JAM. Kidney Disease. 8; 1986:356-367.

  • Satrija F, Nansen P, Murtini S, He S. Anthelminitic activity of papaya latex against patent Heligmosomoides polygyrus infection in mices. J. Ethanopharmacol., 48(3); 1995: 161-164.

  • Shemesh O, Golbe TZ, Kriss JP, Myers BD. Limitation of creatinine as a filtration marker in glomerilpoathic patient, Kidney International., 28;1985:830-838.

  • Shivanada nayak B. Lexely pinto Pereira and Dale Maharaj. Wound healing activity of Carica papaya L. in experimentally induced diabetic rats. Indian Journal of Experimental Biology., 45; 2007: 739-743.

  • Sofowara A. Medicinal plants and Traditional medicine in Africa. Spectrum Books Ltd., Ibadan, Nigeria. 1993: 289.

  • Subal Debnath, Nilesh Babre, Majaunath, Nephroprotective evaluation of Ethanolic extract of the seed of papaya and pumpkin fruit in cisplatin. Induced nephrotoxicity. Journal of Pharmaceutical Science and Technology. 2(6); 2010: 241-246.

  • Sundin DP, Sandoval R, Molitoris BA. Gentamicin Inhibits Renal Protein and phospholipid metabolisms in rats. Implications involving in molecular Trafficking J. Am. Soc., Nephrol., 12; 2001: 114-123.

  • Zar JH. Englewood Cliffes NJ. In Biostatistical Analysis. Prentice hall, Inc 1984.


Abstract Views: 235

PDF Views: 0




  • Potential of Carica papaya Against Gentamicin Induced Nephrotoxic Rats

Abstract Views: 235  |  PDF Views: 0

Authors

S. Saranya
PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Mannargudi-614001, Tamil Nadu, India
R. Anuradha
PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Mannargudi-614001, Tamil Nadu, India

Abstract


The present study was desined to evaluate the nephroprotective effect of ethanolic extracts of seeds of Carica papaya against gentamicin induced nephrotoxicity in albino rats. Oral administration of gentamicin (5mg/100g body weight/day) shows the significantly reduction in serum urea, uric acid, creatinine and protein, level were significantly decreased when compared to the control rats. Ethanolic extracts of seeds of Carica papaya administration (40 mg/kg b. wt/day) brought about the significant changes in biochemical parameters. The present work indicates that the Carica papaya extracts has showed their protective role against gentamicin induced nephrotoxicity and its more effective in preventing kidney damage that treating it.

Keywords


Nephrotoxicity, Renal Markers, Gentamicin, Carica papaya.

References