Research Journal of Pharmacology and Pharmacodynamics

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Antibacterial Activity of Aspergillus oryzae against some Human Pathogens


Affiliations
1 Dept. of Botany and Microbiology, A.V.V.M Sri Pushpam College (Autonomous), Poondi, Thanjavur (Dt.) - 613 503, Tamil Nadu, India
2 Dept. of Microbiology, Thanthai Hans Roever College of Arts and Science, Elambalur, Perambalur - 621 212, Tamil Nadu, India
     

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The marine fungi occurring on the wood samples were studied. Diversity of marine fungi colonizing the lignicolous wood samples was assessed and their distribution pattern was determined. The antibacterial activity of Aspergillus oryzae was tested against five human pathogens by agar well diffusion method. Based on the results, the compounds were separated by Thin Layer Chromatography (TLC) and these compounds were tested against three human bacterial pathogens. The separated compounds were further analyzed by Fourier Transform Infrared Spectroscopy (FTIR) to identify the functional groups, for the antibacterial activity.

Keywords

Aspergillus oryzae, FTIR, TLC, Sterol.
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  • Annette, N. J., 2009. A novel procedure for strain classification of fungal mycelium By cluster and artificial neural network analysis of Fourier Transform infrared(FTIR) spectra. Analyst.134: 1215-1223.

  • Bugni. T.S., Ireland, C.M., 2004. Marine derived fungi a chemically and biologically diverse group of microorganisms. Nat. Prod. Rep. 21: 143-163.

  • Korzybski,T., Kowszyk - Gindifer, and Kurylowicz., 1967. Antibiotics, Vol.2. Pergamon press, New York.

  • Perez, C., Paul, M., Bazerque, P., 1990. Antibiotic assay by agar well diffusion method. Acta. Biol. Med. Exp., 15: 113-115.

  • Singh, R., Sharma, M., Joshi, P., Rawat, D.S., 2008. Clinical status of anti-cancer agents derived from marine sources. Anticancer agents Med Chem. 8: 603-617.

  • Wagner, R. and Bladt, S.D.,1996. Plant Drug Diagnosis, A thin layer chromatography, pp:384.

  • Yanagihara, N., Sasaki-Takahashi, M., Sugahara, T., Yamamoto, S., Shinomi, M., Yamashita, E., Hayashida, M., Andoh, T., 2005. Leptosins isolated from marine fungus Leptosphaeraia species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of AKT/Protein Kinase B. Cancer. Sci. 96: 816-824.

  • Young, X., Jun, L., An-guol., and Jing-Xia, C., 2003.Structure identification for the compound I separated and purified from taxoids produced endophytic fungi (Alternaria alternate var. taxi 1011) J.For.Res.14(3) : 217-233.


Abstract Views: 317

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  • Antibacterial Activity of Aspergillus oryzae against some Human Pathogens

Abstract Views: 317  |  PDF Views: 1

Authors

G. Senthilkumar
Dept. of Botany and Microbiology, A.V.V.M Sri Pushpam College (Autonomous), Poondi, Thanjavur (Dt.) - 613 503, Tamil Nadu, India
A. Josphine
Dept. of Botany and Microbiology, A.V.V.M Sri Pushpam College (Autonomous), Poondi, Thanjavur (Dt.) - 613 503, Tamil Nadu, India
P. Madhanraj
Dept. of Microbiology, Thanthai Hans Roever College of Arts and Science, Elambalur, Perambalur - 621 212, Tamil Nadu, India
A. Panneerselvam
Dept. of Botany and Microbiology, A.V.V.M Sri Pushpam College (Autonomous), Poondi, Thanjavur (Dt.) - 613 503, Tamil Nadu, India

Abstract


The marine fungi occurring on the wood samples were studied. Diversity of marine fungi colonizing the lignicolous wood samples was assessed and their distribution pattern was determined. The antibacterial activity of Aspergillus oryzae was tested against five human pathogens by agar well diffusion method. Based on the results, the compounds were separated by Thin Layer Chromatography (TLC) and these compounds were tested against three human bacterial pathogens. The separated compounds were further analyzed by Fourier Transform Infrared Spectroscopy (FTIR) to identify the functional groups, for the antibacterial activity.

Keywords


Aspergillus oryzae, FTIR, TLC, Sterol.

References