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Wound Healing Effects of Mussaenda frondosa Extracts on Second Degree Superficial Burned Rat


Affiliations
1 Dept of Pharmacognosy, Maratha Mandal's College of Pharmacy, Belgaum, 560010, Karnataka, India
2 Dept of Pharmaceutics, Government College of Pharmacy, Bengaluru, India
3 Dept of Pharmacology, Maratha Mandal's College of Pharmacy, Belgaum, India
     

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Background: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that leaves of Mussaenda frondosa Linn (MF) has shown antimicrobial and antiinflammatory activities. This study investigates the healing effect of MF extract in comparison with SSD in second degree burn wounds.

Methods: Adult albino rats of weight around 150-200 gm were divided into 4 groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with alcoholic extract (AE) cream of MF at concentrations of 10% (AE10) and aqueous extract (AQE) cream of MF at concentrations of 10% (AQE10) and the control group which received no treatment. The duration of treatment was 16 days.

Results: This study revealed that AE and SSD noticeably improved reepithelization, lipid peroxde, and collagen bundle synthesis and had a noticeable effect on TBAR compared with the control group.


Keywords

Mussaenda frondosa Linn, Silver Sulfadiazine, Burn Rat.
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  • Wound Healing Effects of Mussaenda frondosa Extracts on Second Degree Superficial Burned Rat

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Authors

Suhas A. Patil
Dept of Pharmacognosy, Maratha Mandal's College of Pharmacy, Belgaum, 560010, Karnataka, India
V. G. Joshi
Dept of Pharmaceutics, Government College of Pharmacy, Bengaluru, India
S. N. Sambreka
Dept of Pharmacology, Maratha Mandal's College of Pharmacy, Belgaum, India

Abstract


Background: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that leaves of Mussaenda frondosa Linn (MF) has shown antimicrobial and antiinflammatory activities. This study investigates the healing effect of MF extract in comparison with SSD in second degree burn wounds.

Methods: Adult albino rats of weight around 150-200 gm were divided into 4 groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with alcoholic extract (AE) cream of MF at concentrations of 10% (AE10) and aqueous extract (AQE) cream of MF at concentrations of 10% (AQE10) and the control group which received no treatment. The duration of treatment was 16 days.

Results: This study revealed that AE and SSD noticeably improved reepithelization, lipid peroxde, and collagen bundle synthesis and had a noticeable effect on TBAR compared with the control group.


Keywords


Mussaenda frondosa Linn, Silver Sulfadiazine, Burn Rat.

References