Open Access
Subscription Access
Open Access
Subscription Access
Antisecretory and Antiulcer Activity of Cartaeva nurvala against Indomethacin plus Pyloric Ligation Induced Gastric Ulcers in Rats
Subscribe/Renew Journal
Settings and Design: Rats treated with two oral doses of indomethacin suspension as a standard dose, at an interval of fifteen hours, two hours after the second dose of indomethacin, Pyloric ligation was carried the rats were destroyed by over-dose of anesthetic ether. Pyloric ligation was done only to collect the gastric content for analysis.
Methods and Material: Indomethacin plus pyloric ligation (PL) induced gastric ulceration model was used in the study.
Statistical analysis used: The results were expressed as mean ± SEM. The significance of difference between mean values for the various treatments was tested using the unpaired student 't' test P<0.05 was considered statistically significant.
Results: Treatment from Cartaeva nurvala crude extract for fifteen days significantly reduced ulcer index when compared with control group. Crude extract also significantly reduced volume of gastric secretion, free acidity and total acidity. A significant increase in total carbohydrate (TC) and TC/total protein (TP) ratio of gastric juice was also observed. No significant change in the total protein was noted.
Conclusions: Cartaeva nurvala was found to be an effective anti-ulcerogenic agent, whose activity can well be compared with that of ranitidine hydrochloride.
Keywords
- Mishra A, Arora S, Gupta R, Punia RK and Sharma AK. Effect of Feronia elephantum (Corr) Fruit Pulp Extract on Indomethacin-induced Gastric Ulcer in Albino Rats. Tropical J of Pharmaceutical Res. 2009; 8 (6): 509-514.
- McCofferty DM, Granger DN, Wallace J L. Indomethacin induced gastric injury and leukocyte adherence in arthritic versus healthy rats. Gastroenterology. 1995;109: 1173 - 1180
- Shay H, Komarov S A, Fels SE. Meraze D, Gruenstein M, Siplet HA. A simple method for the uniform production of gastric ulceration in the rats. Gastroenterology. 1945;5:43-61.
- Ganguly AK, Bhatnagar OP.Effect of bilateral adrenalactomy on production of restraint ulcer in the stomach of albino rats. Can. J Physiol Pharmacol .1973;51:748-750.
- Parmar NS, Tariq M, Ageel AM. Studies on the gastroulcerogenic effect of pylorus ligated, hypothermic restraint stress, reserpine, indomethacin and aspirin in morphine dependent rats. Alcohol Drug Res. 1987; 7:34-39.
- Hawk A Hawk's. Physiological Chemistry.. McGraw Hill Book Co. 1965;14 ed: pp. 483 - 486.
- Nair B R. Investigation of the Venom of South Indian Scorpion Heterometrus Scaper. Ph. D. Thesis of the University of Kerala, 1976:39.
- Lowry OH, Rosenborough NJ, Farr AL. Randal RJ. Protein measurement with Folin phenol reagent. J Biol Chem. 1951; 193:265 - 275.
- Mahajan B.K. Significance of difference in mean. Methods in Biostatistics. ed. Medical Publishers Ltd . 1995; 5th pp 129 - 153.
- Odabasoglu F , Cakir A , Suleyman H , Aslan A , Bayir Y, Halici ,M et al. Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. Journal of Ethnopharmacology .2006;103:59-65.
- Shirode D, Patel T, Roy S P. Anti-ulcer properties of 70% ethanolic extract of leaves of Albizzia lebbeck. Pharmacognosy Magazine.
- Rees WDW, Gibbon LC, Turnberg LA. Effect of non-steroidal anti-inflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro. Gut .1983, 24:784-789.
- Rainford KD. Side effects of anti-inflammatory/analgesic drugs Epidemiology and gastrointestinal tract. Trends Pharmacol Sci. 1984; 5:156-159.
- Mozsik GY, Kiss B, Javor J, Krausz M, Toth E. Effect of cholinesterase inhibitor treatment on the phosphorus and nucleic acid metabolism in the stomach wall. Pharmacol. 1969; 2:45-59.
- Ogle J, Cho C, Tang M, Koo M. Eur J Pharmacol. 1985;112: 399-404.
Abstract Views: 319
PDF Views: 2