Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Multidose Therapy (MDT) Treatment for Helicobacter Pylori Infection Leading to Gastric Ulcer and Carcinoma: A Review


Affiliations
1 Department of Pharmaceutics Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
     

   Subscribe/Renew Journal


The realization that Helicobacter pylori is one of the most important etiological factors for peptic ulcer has had an enormous impact on approach to the management of ulcer disease leading to gastritis, gastric cancer and duodenal ulcer which has been a major problem in India as well as western and southern country. Helicobacter pylori is one of the microorganism which can easily survive in highly acidic medium in gastrointestinal tract even though they can survive in acid of car battery; so, there are various treatment schedules just like single, double and triple drug therapy including antibiotics, proton pump inhibitors, antacids, antiamoebic and H2 blockers. These drugs are used in the combination therapy for a specific period of time and high eradication rate 86-90% of Helicobacter pylori is observed in case of triple drug therapy, for the best result triple drug therapy (proton pump inhibitors, antibiotics & H2 blockers) along with antacids must be employed in the treatment of Helicobacter pylori infection leading to gastric ulcer and gastric carcinoma because triple drug therapy reduces total duration of therapy.

Keywords

H. pylori, Gastritis, Duodenal Ulcer, Gastric Carcinoma.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Mehmood Arshad, Akram M., Shahab-uddin, Ahmed Afzal, Khan Usmanghani, Hannan Abdul, Mohiuddin E., Asif M. Helicobacter pylori: an introduction. IJABPT. Volume: I: Issue-3: Nov-Dec -2010. ISSN 0976-4550.

  • Parsonnet Julie, Friedman D. Gary, Vandersteen P. Daniel, Chang Yuan, Vogelman H. Joseph, Orentreich Norman, and Sibley K. Richard. Helicobacter pylori Infection and the Risk of Gastric Carcinoma. The New England Journal of Medicine. 1991; 325:1127-1131october 17, 1991.

  • Yvonne T.H.P. van Duynhoven1 & Rob de Jonge. Transmission of helicobacter pylori : a role for food. Bulletin of the World Health Organization. 2001, 79: 455–460.

  • Watanabe Takeshi , Tada Mayumi , Nagai Hirofumi , Sasaki Satoshi , Nakao Masafumi. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Official Journal of AGA Institute. Volume 115, Issue 3 , Pages 642-648, September 1998.

  • Kawamura Masashi, Abe Shu, Oikawa Keisuke, Terai Shiho, Saito Masahiro, Shibuya Daisuke, Kato Katsuaki, Inomata Yoshifumi, Ohara Shuichi, Shimosegawa Tooru. Digestive Endoscopy. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society. Volume 23, Issue 1, pages 37–42, January 2011.

  • Malaty M. Hoda. Epidemiology of Helicobacter pylori infection. Best Practice & Research Clinical Gastroenterology. Vol. 21, No. 2, pp. 205-214, 2007. Available from: URL: <http://www.sciencedirect.com>

  • Perez-Perez I. Guillermo, Rothenbacher Dietrich and Brenner Hermann. Epidemiology of Helicobacter pylori Infection. Volume 9, Supplement 1, 2004.

  • BSCI 424 pathogenic microbiology fall 2000.university of maryland. Available from URL:<http://www.life.umd.edu/classroom/bsci424/PathogenDescriptions/Helicobacter.htm>

  • Olbe Lars, Fandriks Lars, Hamlet Annika, Svennerholm Ann-Mari and Thoreson Ann-Catrin. Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease. World Journal of Gastroenterology. 2000; 6(5):619-623, ISSN 1007-9327.

  • Andersen AP, Elliott DA, Lawson M, Barland P, Hatcher VB and Puszkin EG. Growth and morphological transformations of Helicobacter pylori in broth media [In Process Citation]. Journal of Clinical Microbiology, Nov 1997, 2918-2922, Vol 35, No. 11.

  • Bode G., Mauch F. And Malfertheiner P. The coccoid forms of Helicobacter pylori. Criteria for their viability. Epidemiol. Infect. (1993), 111, 483-490.

  • Grubel P, Hoffman JS, Chong FK, Burstein NA, Mepani C and Cave DR. Vector potential of houseflies (Musca domestica) for Helicobacter pylori. Journal of Clinical Microbiology, 06 1997, 1300-1303, Vol 35, No. 6.

  • Dunn BE, Cohen H and Blaser MJ. Helicobacter pylori. Clinical Microbiology Reviews, Oct 1997, 720-741, Vol 10, No. 4.

  • Tsang KW, Lam SK. Extragastroduodenal conditions associated with Helicobacter pylori infection. Hongkong Medical Journal. June 1999; 5:169-174 Vol. 5 No 2.

  • Salmela K. S., Roine R. P. , Hook-Nikanne J. , Kosunen T. U. and Salaspuro M. Acetaldehyde and Ethanol Production by Helicobacter pylori. Scandinavian Journal of Gastroenterology. 1994, Pages 309-312, Vol. 29, No. 4.

  • Konturek S.J., Konturek P.C., Konturek J.W., Plonka M., Czesnikiewicz-Guzik M., Brzozowski T., Bielanski W. Helicobacter pylori and its involvement in gastritis and peptic ulcer formation. Available from: URL:< http://www.jpp.krakow.pl/journal/archive/09_06_s3/articles/03_article.html>

  • Beswick J Ellen, Suarez Giovanni, Reyes E Victor. H pylori and host interactions that influence pathogenesis. World Journal of Gastroenterology. 2006 September 21; 12(35): 5599-5605. ISSN 1007-9327. Available from URL: <http://www.wjgnet.com/1007-9327/12/5599.asp>

  • Kusters G. Johannes, Vliet H. M. van Arnoud, and Kuipers J. Ernst. Pathogenesis of Helicobacter pylori Infection. Clinical Microbiology reviews, july 2006, p. 449–490, Vol. 19, No. 3.

  • EL-Zimaity HM., Recent advances in the histopathology of gastritis.Current Diagnostic pathology, 13, 2007, 340-348

  • Dixon MF., Genta RM., Yardley J., Classification and grading of gastritis. Am J Surg Pathol, 20, 1996, 1161-1181.

  • Elseweidy M. Mohamed ,Taha M. Mona , Younis Nahla N. Younis, Ibrahim S. Khadiga , Hamouda A. Hamdi , Eldosouky A. Mohamed, soliman Hala , Ghate Samir. Pattern of gastritis as manipulated by current state of Helicobacter pylori infection. International Journal of Biology and Biomedical Engineering. Issue 1, Volume 4, 2010.

  • Dixon MF. Helicobacter pylori and peptic ulceration: histopathological aspects. J Gastroenterol Hepatol 1991;6:125–30.

  • Moayyedi Paul, Wason Catriona, Peacock Robert, Walan Anders, Bardhan Karna, Axon T. R. Anthony, and Dixon F. Michael. Changing Patterns of Helicobacter pylori Gastritis inLong-Standing Acid Suppression. Blackwell Science page no.206-214, Volume 5 Number 4 2000.

  • Kato Ikuko , Nomura M. Y. Abraham , Stemmermann N. Grant , Chyou Po-Huang . A Prospective Study of Gastric and Duodenal Ulcer and Its Relation to Smoking, Alcohol, and Diet. American Journal of Epidemiology 1992, 135 (5): 521-530.

  • Hompes A David. H pylori symptoms. Available from URL: <http://hpylori-symptoms.com/h-pylori-symptoms/>

  • Gold D. Benjamin, Colletti B. Richard, Abbott Myles, Czinn J. Steven, Elitsur Yoram, Hassall Eric, Macarthur Colin, Snyder John, and Sherman M. Philip. Helicobacter pylori Infection in Children: Recommendations for Diagnosis and Treatment. Journal of Pediatric Gastroenterology and Nutrition, November 2000:490–497, Vol. 31, No. 5.

  • Hardin J. Frederick, Wright A. Richard. Helicobacter pylori: Review and Update. Hospital Physician May 2002.Available from URL: <www.turner-white.com>

  • Jiang Zheng, Huang Ai-Long, Tao Xiao-Hong, Wang Pi-Long. Diagnosis of Helicobacter pylori infection and diseases associated with Helicobacter pylori by Helicobacter pylori outer membrane proteins. World Journal of Gastroenterology 2004; 10(23):3464-3469, ISSN 1007-9327.

  • Trautmann Karolin, Stolte Manfred, Miehlke Stephan. Eradication of H pylori for the prevention of gastric cancer. World Journal of Gastroenterology 2006 August 28; 12(32): 5101-5107, ISSN 1007-9327.

  • Donovan J. Arthur, Berne V. Thomas, Donovan A. John. Perforated Duodenal Ulcer: An Alternative Therapeutic Plan. Archives of surgery VOL 133, NOV 1998. Available from URL:<http://archsurg.amaassn.org/cgi/content/full/133/11/1166>

  • Aguilar R. German, Ayala Guadalupe, Fierros-Zarate Geny. Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention.SciELO Public Health vol.43, no.3, may-june 2001.

  • Kate Vikram , Ananthakrishnan N . Treatment of helicobacter pylori infection: A review. Indian journal of pharmacology 2001; 33: 410-416.

  • Gerrits M Monique, Vliet HM van Arnoud, Kuipers J Ernst, Kusters G Johannes. Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. The Lancet Infectious Diseases. Volume 6, Issue 11, November 2006, Pages 699-709.

  • Stenstrom Bjorn Mendis Aruni, Marshall Barry. Helicobacter pylori: the latest in diagnosis and treatment. Reprinted from Australian Family Physician Vol. 37, No. 8, August 2008.


Abstract Views: 320

PDF Views: 2




  • Multidose Therapy (MDT) Treatment for Helicobacter Pylori Infection Leading to Gastric Ulcer and Carcinoma: A Review

Abstract Views: 320  |  PDF Views: 2

Authors

Amit Alexander
Department of Pharmaceutics Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
D. K. Tripathi
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
Ajazuddin
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
Mukesh Singh
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
Monesh Sahu
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India
Swarna
Rungta College of Pharmaceutical Sciences and Research, Bhilai, India

Abstract


The realization that Helicobacter pylori is one of the most important etiological factors for peptic ulcer has had an enormous impact on approach to the management of ulcer disease leading to gastritis, gastric cancer and duodenal ulcer which has been a major problem in India as well as western and southern country. Helicobacter pylori is one of the microorganism which can easily survive in highly acidic medium in gastrointestinal tract even though they can survive in acid of car battery; so, there are various treatment schedules just like single, double and triple drug therapy including antibiotics, proton pump inhibitors, antacids, antiamoebic and H2 blockers. These drugs are used in the combination therapy for a specific period of time and high eradication rate 86-90% of Helicobacter pylori is observed in case of triple drug therapy, for the best result triple drug therapy (proton pump inhibitors, antibiotics & H2 blockers) along with antacids must be employed in the treatment of Helicobacter pylori infection leading to gastric ulcer and gastric carcinoma because triple drug therapy reduces total duration of therapy.

Keywords


H. pylori, Gastritis, Duodenal Ulcer, Gastric Carcinoma.

References