Open Access
Subscription Access
Open Access
Subscription Access
Studies of Antipyretic and Anti-Inflammatory Activities of Odina woodier Leaves Extracts
Subscribe/Renew Journal
Antipyretic and anti-inflammatory activities of different extracts of Odina woodier leaves were studied by observing decrease in rectal temperature and reduction in paw edema using albino rats of both sexes. Animals were divided into ten groups, each consisting of six animals. Group 1 served as control and Group 2 received the standard drug. Group 3-10 received various extracts of Odina woodier leaves. Group 3 received ethanol extracts of 200mg/kg and Group 4 received 400mg/kg. Group 5 and Group 6 received ethyl acetate extracts of 200mg/kg and 400mg/kg respectively. Similarly Group 7 and Group 8 received chloroform extracts of 200mg/kg and 400mg/kg. Group 9 received 200mg/kg and Group 10 received 400mg/kg petroleum ether extracts of Odina woodier leaves. For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension and for anti-inflammatory activity, inflammation was induced using 1% carageenan suspension. The results showed that all the extracts were found to have both antipyretic and anti-inflammatory activities. Among these four extracts, ethanol extract of 400 mg/kg have shown same antipyretic activity after four hours of drug administration as that of the standard Paracetamol drug which caused the reduction of temperature of 1.03 and 1.02 for the extracts and Paracetamol drug . 400mg/kg of ethyl acetate extract after two hours have shown higher anti-inflammatory activity (40.43%) with a probability < 0.001 than the chosen standard drug diclofenac sodium(39.75%) available as an anti-inflammatory drug in the market.
Keywords
Antipyretic, Anti-Inflammatory, Carageenan, Pyrexia and Odina Woodier.
Subscription
Login to verify subscription
User
Font Size
Information
- Kiritikar, K.R. and Basu, B.D. Indian Medicinal Plants, 1935, 2nd Edition, International Book Distributors, Book Sellers and Publishers, Dehradun.
- Chidanbarathanu, S. (1995) Index of herbs in languages. Siddha Medical Literature Research centre, Madras.
- Kiritikar, K.R. and Basu, B.D. (1987) Indian Medicinal Plants, International Book Distributors, Book Sellers and Publishers, Dehradun.
- Ramakrishnan,P.N., Palanichamy,S(2004). Extraction and Galenicals/Pharmaceutics-1Ed.9, Jai publishers, Madurai.PP.82-85.
- Niazi J, Vikas Gupta V, Chakarborty P,Kumar P; Anti-inflammatory and antipyretic activity of aleuritis moluccana leaves .Asian Journal of Pharmaceutical and Clinical Research , 2010, Vol.3 Issue 1, January-March 35-37.
- Vogel H.G. ”Drug discovery and evaluation”,2nd edition,772.
- Hajare S W, Chandra S, Tandan S. K., Sharma J, Lal J,Telang A G; Analgesic and antipyretic activity of Dalbergia Sissoo Leaves. Indian Journal of Pharmacology 2000, 32, 357-360.
- Cheng L, Ming-liang H, Lars B et al. Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. Acta Pharmacologica Sinica 2005, 26, 926-933.
- Brownlee.G.(1937). A comparison of the antipyretic activity and toxicity of Phenacetin and aspirin. Journal of Pharmacy and Pharmacology.10:609-611.
- Asha.V.V., Pushpangadhan, P(1999). Antipyretic activity of Cardiospermum halicacabum Linn. Indian journal of Experimental biology.37(4):411-414.s
- Winter CA, Risley EA, Nuss CW. Carrageenan induced edema in hind paw of rat as an assay for anti-inflammatory drugs. In: Proc. Soc. Exp. Biol. Med. 1962, 11,544-547.
- Dimartins, M.J., Campbell, J.R.,Wolff,G.K., Hanna.N(1987). The pharmacology of arachidonic acid induced rat paw oedema..Agents actions.21(3-4):303-305.
- K. M. Basavaraja et al .J. Chem. Pharm. Res., 2010, 2(6), 387-392.
Abstract Views: 248
PDF Views: 2