Research Journal of Pharmacology and Pharmacodynamics

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Pharmacodynamic Influence of Vitamin C and Esomeprazole on Gastro Protection in Pylorus Ligation and Aspirin Induced Ulcers in Rats


Affiliations
1 Department of Pharmacology, H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka, India
2 H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka., India
     

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Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of Vitamin C and Esomeprazole and their combination on Gastro intestinal parameters in pylorus ligation and aspirin induced ulcers in rats. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for aspirin induced ulcer model. The antiulcer effect of the combination of vitamin C 4.5 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole. The percentage protection of combination was 85% as compared to standard esomeprazole 80% in pylorus ligation model. In the aspirin induced model the percentage protection of combination was 90% as compared to standard esomeprazole 85%. Thus the combination group was found to be synergistic in nature when compared to esomeprazole alone in both the models.

Keywords

Antiulcer Activity, Vitamin C, Esomeprazole, Pylorus Ligation, NSAIDs, Ulcer Index.
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  • Hoogerwerf WA and Pasricha PJ (2001). Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophal reflux disease In: Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Ed. Maxwell Mac Millan International Eds. Pergamon Press, Inc. Maxwell House, Fairview Park, Elmsford, New York 10523, USA, 1005- 1020.

  • Ganong WF (1989). Regulation of Gastrointestinal Function in: Review of Medical Physiology. 14th Ed. Prentice-Hall Englewood Cliffs, New Jersey, USA, 448-466.

  • Guyton AC (1991). General Principles of Gastrointestinal Function in: Textbook of Medical Physiology.8thEd.W.B.SaundersCompany,Harcourt Brace Jovanovich, Inc. Philadelphia, PA 19106 USA, 688-697.

  • Walter and Isreal (1996). General Pathology, 7th Ed. Churchill Livingstone Inc., 650 Avenues, New York, NY 10011, USA 128, 133-134.

  • Shemerovskii KA and Nikul'shina SA (1998). Myoelectric activity of the rabbit stomach and duodenum following neurogenic and humoral effects. Ross Fiziol Zh Im I M Sechenova (Russian); 84(9): 931-939.

  • Dr Dhrubo Jyoti Sen. Herbal Antioxidants: A Great Hope for future. Pharma Times. 2008;40(12): 22-36.

  • Jan C Becker, Nina Grosser, Peter Boknik, Henning Schroder, Wolfram Domschke, Thorsten Pohle. Gastro Protection by Vitamin C-a heme oxygenase-1-dependent mechanism. Biochemical and Biophysical Research Communications. 2003; 312(2): 507-12.

  • Pommerien W, Schultze V, Braden B, Lembcke B, Wrangstadh M, Londong W. Dose-response of Omeprazole combined with amoxycillin on duodenal ulcer healing and eradication of Helicobacter pylori. Aliment Pharmacol Ther 1996; 10: 303-8.

  • Laurence DR, Bacharach AL. Evaluation of drug activities and pharmacometrics. London and New York. Academic press; 1:160-61.

  • Shay M, Komarov SA, Fels D, Meranze D, Gruenstein H and Siplet. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945; 5:43-61.

  • Raju. D., Ilango. K., Chitra. V., Ashish. K. Evaluation of Antiulcer activity of methanolic extract of Terminalia Chebula fruits in experimental rats. Journal of Pharmaceutical Sciences and research 2009;1(3):101-107.

  • R. K. Goel, S. Gupta, R. Shankar, and A. K. Sanyal, J Ethnopharmacol. 18, 1986.33.

  • Patil S.S., Bhide A.A. and Gorle A.M. Antiulcer activity and Ant inflammatory Studies on acacia catechu. Indian Drugs 2010; 47(2):52-53.

  • S.K. Kulkarni. Hand book of experimental Pharmacology, Vallabh Prakashan New Delhi, 2002 pp. 149-150.

  • H.Gerhard Vogel. Drug Discovery and Evaluation, Springer- Verlag Berlin Heidelberg, New Your 2002 pp. 868.

  • Grover JK, Vats V. Proton pump inhibitors. Trop Gastroenterol 1999;20:16-28.

  • Rainsford KD. The effect of 5-lipoxygenase inhibitors and leukotrien antagonists on the development of gastric lesion by non steroidal anti-inflammatory drugs in mice.Agents Actions 1987; 21:316-9.

  • Goel RK and Bhattacharya SJL. Gastroduodenal mucosal defense and mucosal protective agents. Indian J Exp Bio 1991; 29:701-14.

  • Mahendran P, Sabitha KE, Shyamaldevi CV. Prevention of HClethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. J Expl Biol 2002:58-62.


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  • Pharmacodynamic Influence of Vitamin C and Esomeprazole on Gastro Protection in Pylorus Ligation and Aspirin Induced Ulcers in Rats

Abstract Views: 284  |  PDF Views: 0

Authors

M. Nitin
Department of Pharmacology, H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka, India
U. Mohan Reddy
H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka., India
S. M. Sayeed Ul Hasan
H.K.E.S's, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka., India

Abstract


Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of Vitamin C and Esomeprazole and their combination on Gastro intestinal parameters in pylorus ligation and aspirin induced ulcers in rats. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for aspirin induced ulcer model. The antiulcer effect of the combination of vitamin C 4.5 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole. The percentage protection of combination was 85% as compared to standard esomeprazole 80% in pylorus ligation model. In the aspirin induced model the percentage protection of combination was 90% as compared to standard esomeprazole 85%. Thus the combination group was found to be synergistic in nature when compared to esomeprazole alone in both the models.

Keywords


Antiulcer Activity, Vitamin C, Esomeprazole, Pylorus Ligation, NSAIDs, Ulcer Index.

References