Research Journal of Pharmacology and Pharmacodynamics

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Study of Antidiabetic Activity of the Stem Bark Extract of Holoptelea integrifolia (Roxb.)


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1 B.N. College of Pharmacy, Udaipur Rajasthan, India
     

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The plant Holoptelea integrifolia (Roxb.) belongs to Ulmaceae family. This species is used traditionally for the treatment of edema, diabetes, leprosy, skin diseases, intestinal disorders and piles. The present study of antidiabetic activity of the stem bark extract of Holoptelea integrifolia (Roxb.) was investigated in alloxan induced diabetic rats. The treatment was continue for 21 days. High mortality rate was seen in alloxan induced diabetic rats. The blood glucose level, body weight and lipid profile was estimated. The blood glucose level decreases gradually in the animals treated with the bark extract (250 mg/kg b.w.and 500 mg/kg b.w., orally), it was found to be statistically significant after 15 day treatment at dose level of 500 mg/kg.The prevention of loss of body weight in diabetic animals was found to be significant on day 15 in the animals of both treatment groups.

Keywords

Holoptelea integrifolia, Alloxan, Blood Glucose Level, Diabetes Mellitus.
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  • Study of Antidiabetic Activity of the Stem Bark Extract of Holoptelea integrifolia (Roxb.)

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Authors

Jyoti Sharma
B.N. College of Pharmacy, Udaipur Rajasthan, India
S. C. Sharma
B.N. College of Pharmacy, Udaipur Rajasthan, India
Y. S. Sarangdevot
B.N. College of Pharmacy, Udaipur Rajasthan, India
Bhupendra Vyas
B.N. College of Pharmacy, Udaipur Rajasthan, India

Abstract


The plant Holoptelea integrifolia (Roxb.) belongs to Ulmaceae family. This species is used traditionally for the treatment of edema, diabetes, leprosy, skin diseases, intestinal disorders and piles. The present study of antidiabetic activity of the stem bark extract of Holoptelea integrifolia (Roxb.) was investigated in alloxan induced diabetic rats. The treatment was continue for 21 days. High mortality rate was seen in alloxan induced diabetic rats. The blood glucose level, body weight and lipid profile was estimated. The blood glucose level decreases gradually in the animals treated with the bark extract (250 mg/kg b.w.and 500 mg/kg b.w., orally), it was found to be statistically significant after 15 day treatment at dose level of 500 mg/kg.The prevention of loss of body weight in diabetic animals was found to be significant on day 15 in the animals of both treatment groups.

Keywords


Holoptelea integrifolia, Alloxan, Blood Glucose Level, Diabetes Mellitus.

References