Research Journal of Pharmacology and Pharmacodynamics

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Natural Antioxidants: A Review on Therapeutic Applications


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1 Progressive Education Society's Modern College of Pharmacy, Sector No. 21, Yamunanagar, Nigdi, Pune-44, Maharashtra, India
     

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Free radicals cause oxidative damage to lipids, proteins and DNA, eventually leading to many chronic diseases such as cancer, diabetes, aging, and other degenerative diseases in humans. Reactive oxygen species (ROS) such as superoxide anions (O2-), hydroxyl radical (OH-) and nitric oxide (NO) inactivate enzymes and damage important cellular components causing injury through covalent binding and lipid peroxidation. Antioxidants offer resistance against the oxidative stress by scavenging the free radicals, inhibiting the lipid peroxidation and by other mechanisms and thus prevent disease. The evaluation of the antioxidant properties of specific chemical scavengers is of particular value for their potential use in preventing or limiting the damage induced by free radicals. Various kinds of antioxidants particularly from natural sources such as enzymes, tocopherol, carotenoids, ascorbic acid, polyphenols etc. inhibit the cellular damage mainly through free radical scavenging property. Therefore, antioxidant-based drug formulations are used for the prevention and treatment of complex diseases involving free radicals like atherosclerosis, stroke, diabetes, Alzheimer's disease and cancer. This study reveals the presence of antioxidant activity in varying degrees in many plant materials used. The high efficacy of the medicinal plants provides an alternative to conventional medicine. The cost spent on the fractionation could be avoided, if the crude extract itself has high antioxidant activity. These results may have implications in the use of the extract as a therapeutic agent in the prevention of related diseases.

Keywords

Free Radicals, Oxidative Stress, Antioxidants, Extract.
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  • Natural Antioxidants: A Review on Therapeutic Applications

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Authors

A. V. Jaydeokar
Progressive Education Society's Modern College of Pharmacy, Sector No. 21, Yamunanagar, Nigdi, Pune-44, Maharashtra, India
D. D. Bandawane
Progressive Education Society's Modern College of Pharmacy, Sector No. 21, Yamunanagar, Nigdi, Pune-44, Maharashtra, India
S. S. Nipate
Progressive Education Society's Modern College of Pharmacy, Sector No. 21, Yamunanagar, Nigdi, Pune-44, Maharashtra, India
P. D. Chaudhari
Progressive Education Society's Modern College of Pharmacy, Sector No. 21, Yamunanagar, Nigdi, Pune-44, Maharashtra, India

Abstract


Free radicals cause oxidative damage to lipids, proteins and DNA, eventually leading to many chronic diseases such as cancer, diabetes, aging, and other degenerative diseases in humans. Reactive oxygen species (ROS) such as superoxide anions (O2-), hydroxyl radical (OH-) and nitric oxide (NO) inactivate enzymes and damage important cellular components causing injury through covalent binding and lipid peroxidation. Antioxidants offer resistance against the oxidative stress by scavenging the free radicals, inhibiting the lipid peroxidation and by other mechanisms and thus prevent disease. The evaluation of the antioxidant properties of specific chemical scavengers is of particular value for their potential use in preventing or limiting the damage induced by free radicals. Various kinds of antioxidants particularly from natural sources such as enzymes, tocopherol, carotenoids, ascorbic acid, polyphenols etc. inhibit the cellular damage mainly through free radical scavenging property. Therefore, antioxidant-based drug formulations are used for the prevention and treatment of complex diseases involving free radicals like atherosclerosis, stroke, diabetes, Alzheimer's disease and cancer. This study reveals the presence of antioxidant activity in varying degrees in many plant materials used. The high efficacy of the medicinal plants provides an alternative to conventional medicine. The cost spent on the fractionation could be avoided, if the crude extract itself has high antioxidant activity. These results may have implications in the use of the extract as a therapeutic agent in the prevention of related diseases.

Keywords


Free Radicals, Oxidative Stress, Antioxidants, Extract.

References