Research Journal of Pharmacology and Pharmacodynamics

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Antidiabetic Activities of Euphorbia nivulia Buch in Alloxan Induced Diabetic Rats


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1 Department of Pharmacology, Gautham College, Bengaluru–32, India
     

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Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Diabetes mellitus is often called 'The silent killer', because it causes serious complications without serious symptoms and can affect many of major organs in the body. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Euphorbia nivulia Buch, has been claimed to possess antidiabetic properties in Ayurveda medicine system. The present study was undertaken to screen the hypoglycemic activity of petroleum ether, methanolic and aqueous extracts of Euphorbia nivulia (100mg/kg., b.w.). All the extracts at 100mg/kg., b.w. showed significant decrease in blood glucose level. It also showed the significant response in blood serum parameters (albumin, urea, creatnine, and total protein) lipid parameters such as total cholesterol, LDL, HDL, VLDL and TG when compared with diabetic control.

Keywords

Alloxan, Euphorbia nivulia Buch, Diabetes Mellitus, Blood Glucose, Lipid Profile And Blood Serum Parameters.
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  • Antidiabetic Activities of Euphorbia nivulia Buch in Alloxan Induced Diabetic Rats

Abstract Views: 345  |  PDF Views: 2

Authors

H. S. Nagesh
Department of Pharmacology, Gautham College, Bengaluru–32, India
C. D. Saraswathi
Department of Pharmacology, Gautham College, Bengaluru–32, India
P. Uday Mohan Reddy
Department of Pharmacology, Gautham College, Bengaluru–32, India
P. Archana Swamy
Department of Pharmacology, Gautham College, Bengaluru–32, India
C. Varshitha
Department of Pharmacology, Gautham College, Bengaluru–32, India

Abstract


Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Diabetes mellitus is often called 'The silent killer', because it causes serious complications without serious symptoms and can affect many of major organs in the body. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Euphorbia nivulia Buch, has been claimed to possess antidiabetic properties in Ayurveda medicine system. The present study was undertaken to screen the hypoglycemic activity of petroleum ether, methanolic and aqueous extracts of Euphorbia nivulia (100mg/kg., b.w.). All the extracts at 100mg/kg., b.w. showed significant decrease in blood glucose level. It also showed the significant response in blood serum parameters (albumin, urea, creatnine, and total protein) lipid parameters such as total cholesterol, LDL, HDL, VLDL and TG when compared with diabetic control.

Keywords


Alloxan, Euphorbia nivulia Buch, Diabetes Mellitus, Blood Glucose, Lipid Profile And Blood Serum Parameters.

References