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Protective Effects of Strychnos potatorum Linn. Seeds Extract in Hyperlipidemic Rat Model
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Objective: To investigate the antihyperlipidemic activity of aqueous extract of Strychnos potatorum Linn. Seeds in experimentally induced hyperlipidemia in rats.
Materials and Methods: Hyperlipidemia was induced by single intraperitoneal injection of triton WR 1339 (Tyloxapol) at a dose of 400mg/kg in rats. The doses of 100mg/kg and 200mg/kg of aqueous extract of Strychnos potatorum Linn. Seeds were evaluated for their actions on serum lipid profile. Atorvastatin at a dose of 10mg/kg was used as standard drug. Aqueous extract doses and Atorvastatin were given orally, once immediately and after 24 hours of triton WR 1339 administration. Serum total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and high density lipoprotein cholesterol levels were estimated after 6 hour, 24 hour and 48 hour of triton WR 1339 administration.
Results: Aqueous extracts of Strychnos potatorum significantly (p<0.05) reduced serum total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in dose dependent and time dependent manner when compared to hyperlipidemic group.
Conclusion: The findings of the investigation suggest that aqueous extract of Strychnos potatorum seeds exhibited quite competitive potential when compared with reference drug Atorvastatin against experimentally induced hyperlipidemia.
Keywords
- Ghatak A, Asthana OP. Recent Trends in hyperlipoproteinemias and its pharmacotherapy. Indian Journal of Pharmacology. 27(1); 1995: 14-29.
- Ford ES, Giles WH, Dietz WH. Prevalence of metabolic syndrome among US adults: Findings from third National Health and Nutrition Examination Survey. Journal of the American Medical Association. 287(3); 2002: 356-9.
- Avery Graeme S, Speight Trevor M. Avery's Drug treatment: Principles and practices of clinical pharmacology and therapeutics. Williams and Wilkins, Baltimore.1987.
- WHO Guidelines for the assessment of herbal medicines. Programme on traditional medicines, Geneva: World health Organization, 1991. Available from: <http://whqlibdoc.who.int/hq/1991/WHO_TRM_91.4.pdf.>
- Robert WM, Thomas PB, Laurence LB, John SL, Keith LP. Anti hyperlipidemic agent. In: Goodman and Gillman's The Pharmacological Basis of Therapeutics, Edited by Laurence L. runton. Mc Graw-Hill, New York. 2006; 11th ed: pp. 933-81.
- Kirtikar KR and Basu BD. Indian Medicinal Plants. Vol III. Edited by Basu LM, Allahabad, India. 1933; pp. 1647.
- Kirtikar KR and Basu BD. Illustrated Indian Medicinal Plants. Edited by Mhaskar KS, Blatter E and Cains JF. Sir Satguru's Publications, Delhi, 2000.
- Anonymous, Wealth of India- Raw Materials, Sp-W. Vol. 10, Publications and Information Directorate, CSIR, New Delhi, 1976; pp: 66-67.
- Singh H, Kapoor VK, Phillipson JD and Bisset N.G. Diaboline from Strychnos potatorum. Phytochemistry. 14 (2); 1975: 587- 588.
- Singh A and Bajpai RK. Chemical examination of fixed oil from the seeds of Strychnos potatorum "Linn. f." I mixed fatty acid. Journal of Indian Chemical Society. 52(8); 1975: 768-769.
- Singh H, Kapoor VK and Manhas MS. Investigation of Strychnos Spp. III. Study of triterpenes and sterol of Strychnos potatorum seeds. Planta Medica. 28 (4); 1975: 392-396.
- Singh H, Kapoor VK. Investigation of Strychnos spp. VI - Pharmacological studies of alkaloids of Strychnos potatorum seeds. Planta Medica. 38(2); 1980: 133-137.
- Singh H, Kapoor VK. Investigation of Strychnos spp. IV. Pharmacological studies of alkaloids of Strychnos potatorum. Planta Medica. 29(3); 1976: 226-33.
- Biswas S, Murugesan T, Maiti K, Ghosh L, Pal M, Saha BP. Study on the diuretic activity of Strychnos potatorum Linn. seed extract in albino rats. Phytomedicine. 8(6); 2001: 469-471.
- Biswas S, Murugesan T, Sinha S, Maiti K, Gayen JR, Pal M, Saha BP. Antidiarrhoeal activity of Strychnos potatorum seed extract in rats. Fitoterapia. 73 (1); 2002: 43–47.
- Sanmugapriya E, Senthamil SP and Venkataraman S. Evaluation of antiarthritic activity of Strychnos potatorum Linn. seeds in Freund's adjuvant induced arthritic rat model. BMC Complementary and Alternative Medicine. 10(56); 2010: 1-9.
- Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. Journal of Ethnopharmacology. 105 (1–2); 2006: 154–160.
- The Ayurvedic Pharmacopoeia of India, Part I, Vol-IV. Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga-Naturopathy, Unani, Siddha & Homeopathy (AYUSH), New Delhi. pp. 158-165.
- Sanmugapriya E and Venkataraman S. Toxicological investigations on Strychnos potatorum Linn. Seeds in experimental animal models. Journal of Health Science. 52(4); 2006: 339-343.
- Kellner A, Correll, JW, Ladd AT. 1951. Sustained hyperlipidaemia induced in rabbits by means of intravenously injected surface-active agents. Journal of Experimental Medicine. 93(4); 1951: 373-383.
- Asima C, Satyesh CP. The Treatise on Indian Medicinal Plants, Vol 4, New Delhi, Publications and Information Directorate, CSIR. 2001: pp. 85–87.
- Steinbreg D, Parthasarathy S, Carew TE, Khoo JC, Wititum JL. Beyond cholesterol: modification of LDL that increase it’s atherogenicity. New England Journal of Medicine. 1989; 320: 915-924.
- Kaamanen M, Adlecreutz H, Jauhiainen M, Tikkanen MJ. Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro. Biochemica et Biophysica Acta. 2003; 1631: 147-152.
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