Research Journal of Pharmacology and Pharmacodynamics

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Antidiabetic Potential of Amritarishta Prepared by Traditional and Modern Methods in Alloxan Induced Diabetic Rats


Affiliations
1 Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, India
     

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The objective of the present study was to evaluate the effect of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and marketed Amritarishta on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Amritarishta-T, Amritarishta-M and marketed Amritarishta ( 2 ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard antidiabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly.

Keywords

Cardiovascular Risk, Blood Glucose, Anti-Diabetic, Glutathione, Lipid Profile, Amritarishta, Alloxan.
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  • Antidiabetic Potential of Amritarishta Prepared by Traditional and Modern Methods in Alloxan Induced Diabetic Rats

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Authors

Preeti Tiwari
Department of Pharmacognosy, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Uttar Pradesh, India

Abstract


The objective of the present study was to evaluate the effect of Amritarishta-T and Amritarishta-M prepared by traditional and modern methods respectively and marketed Amritarishta on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Amritarishta-T, Amritarishta-M and marketed Amritarishta ( 2 ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard antidiabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly.

Keywords


Cardiovascular Risk, Blood Glucose, Anti-Diabetic, Glutathione, Lipid Profile, Amritarishta, Alloxan.

References