Research Journal of Pharmacology and Pharmacodynamics

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Drug used in Inflammatory Bowel Disease (IBD) - Brief Review


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1 Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India
     

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have become important health problems. Medical therapy for IBD has advanced dramatically in the last decade with the introduction of targeted biologic therapies, the optimization of older therapies, including drugs such as immunomodulators and 5-aminosalicylic acid (5-ASA), and a better understanding of the mucosal immune system and the genetics involved in the pathogenesis of IBD. The goal of IBD therapy is to induce and maintain remission. Drug delivery to the appropriate site(s) along the gastrointestinal tract also has been a major challenge, and second-generation agents have been developed with improved drug delivery, increased efficacy, and decreased side effect The current treatment paradigm involves a step-up approach, moving to aggressive, powerful therapies only when milder therapies with fewer potential side effects fail or when patients declare themselves to have an aggressive disease. This review focuses on the, symptoms, diagnosis and current treatments for inflammatory bowel disease.

Keywords

Inflammatory Bowel Disease (IBD), 5-Aminosalicylates, Corticosteroids, Infliximab, Herbal Drugs, Symptoms, Diagnosis.
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  • Drug used in Inflammatory Bowel Disease (IBD) - Brief Review

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Authors

Archana R. Dhole
Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India
Giraja G. Shendage
Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India
Shardha Pethkar
Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India
C. S. Magdum
Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India
S. K. Mohite
Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, India

Abstract


Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have become important health problems. Medical therapy for IBD has advanced dramatically in the last decade with the introduction of targeted biologic therapies, the optimization of older therapies, including drugs such as immunomodulators and 5-aminosalicylic acid (5-ASA), and a better understanding of the mucosal immune system and the genetics involved in the pathogenesis of IBD. The goal of IBD therapy is to induce and maintain remission. Drug delivery to the appropriate site(s) along the gastrointestinal tract also has been a major challenge, and second-generation agents have been developed with improved drug delivery, increased efficacy, and decreased side effect The current treatment paradigm involves a step-up approach, moving to aggressive, powerful therapies only when milder therapies with fewer potential side effects fail or when patients declare themselves to have an aggressive disease. This review focuses on the, symptoms, diagnosis and current treatments for inflammatory bowel disease.

Keywords


Inflammatory Bowel Disease (IBD), 5-Aminosalicylates, Corticosteroids, Infliximab, Herbal Drugs, Symptoms, Diagnosis.

References