Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Diuretic Potential of Drakshasava Prepared by Traditional and Modern Methods in Experimental Albino Rats


Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India
2 Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, India
     

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The objective of the present study was to evaluate the diuretic potential of Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Drakshasava-T, Drakshasava-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Drakshasava as Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Drakshasava as Drakshasava-T and Drakshasava-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.

Keywords

Diuretic Potential, Furosemide, Drakshasava, Natriuretic Effect, Kaliuretic Effect.
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  • Evaluation of Diuretic Potential of Drakshasava Prepared by Traditional and Modern Methods in Experimental Albino Rats

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Authors

Preeti Tiwari
Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India
Rakesh K. Patel
Head of Department of Pharmacognosy, Shri S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711, Gujarat, India

Abstract


The objective of the present study was to evaluate the diuretic potential of Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation in experimental rats using furosemide (10 mg/kg p.o.) as a standard diuretic drug. Oral administration of Drakshasava-T, Drakshasava-M and its marketed formulation at the dose of 2.0 ml/kg over a period of 5 h showed a significant increase in urine volume as compared to control group. Both types of Drakshasava as Drakshasava-T and Drakshasava-M prepared by traditional and modern methods respectively and its marketed formulation showed significant increase in sodium, potassium and chloride level in urine sample as compared to control group. The maximum diuretic effect was produced by furosemide. Thus, both types of Drakshasava as Drakshasava-T and Drakshasava-M and its marketed formulation showed significant diuretic, natriuretic and kaliuretic effects.

Keywords


Diuretic Potential, Furosemide, Drakshasava, Natriuretic Effect, Kaliuretic Effect.

References