Research Journal of Pharmacology and Pharmacodynamics

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Antidiabetic and Antihyperlipidemic Activity of Roots of Matricaria recutita on Streptozotocin-Induced Diabetic Rats


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1 Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India
     

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The present study was aimed to evaluate the anti diabetic - activity of Matricaria recutita ischolar_mains against Streptozotocin (STZ) induced experimental rats. Ethanolic extract of ischolar_mains of Matricaria recutita was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Matricaria recutita (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Matricaria recutita (400 mg/kg). An ethanolic extract of Matricaria recutita was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Matricaria recutita on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Matricaria recutita possesses a hypoglycemic and antihyperlipidemic effect.

Keywords

Matricaria Recutita, Glibenclamide, Hypoglycemia, Antihyperlipidemic, Streptozotocin.
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  • Antidiabetic and Antihyperlipidemic Activity of Roots of Matricaria recutita on Streptozotocin-Induced Diabetic Rats

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Authors

Krishna Murti
Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India
Mayank Panchal
Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India
Megha Shah
Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India
Vijay Lambole
Dept. of Pharmacology, Vidyabharti Trust College of Pharmacy, Umrakh, India

Abstract


The present study was aimed to evaluate the anti diabetic - activity of Matricaria recutita ischolar_mains against Streptozotocin (STZ) induced experimental rats. Ethanolic extract of ischolar_mains of Matricaria recutita was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Matricaria recutita (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Matricaria recutita (400 mg/kg). An ethanolic extract of Matricaria recutita was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Matricaria recutita on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Matricaria recutita possesses a hypoglycemic and antihyperlipidemic effect.

Keywords


Matricaria Recutita, Glibenclamide, Hypoglycemia, Antihyperlipidemic, Streptozotocin.

References