Research Journal of Pharmacology and Pharmacodynamics

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Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole Plant in Mice


Affiliations
1 Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
2 GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
     

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The objective of the present study was to investigate the CNS depressant and Anxiolytic activity of the methanolic extract of the whole plant of Celastrus paniculatus Willd. (Family: Celastraceae) in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract (200 mg/kg, 400mg/kg and 600 mg/kg) on the central nervous system (CNS) was evaluated for potentiation of phenobarbitone-induced sleeping time in mice. The results revealed that the methanolic extract of Celastrus paniculatus Willd. Whole plant has reduced the onset of Phenobarbitone-induced sleeping time in mice and prolonged the duration of sleeping time significantly (pCelastrus paniculatus Willd. Whole plant, using Staircase test model, it was revealed that the extract at doses 200 mg/kg and 400mg/kg reduced the number of rearings and decreased the number of steps ascended significantly (pCelastrus paniculatus Willd. whole plant contains some active principles which may possess significant CNS depressant and anxiolytic activity.

Keywords

Celastrus paniculatus Willd., CNS Depressant, Anxiolytic, Potentiation of Phenobarbitone-Induced Sleeping Time, Staircase Test.
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  • Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole Plant in Mice

Abstract Views: 269  |  PDF Views: 2

Authors

Diana Vivian Atigari
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
Sunanda Sabbithi
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
B. Krishna Chaitanya
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
A. Jajisree
GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
C. Ramesh
GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India

Abstract


The objective of the present study was to investigate the CNS depressant and Anxiolytic activity of the methanolic extract of the whole plant of Celastrus paniculatus Willd. (Family: Celastraceae) in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract (200 mg/kg, 400mg/kg and 600 mg/kg) on the central nervous system (CNS) was evaluated for potentiation of phenobarbitone-induced sleeping time in mice. The results revealed that the methanolic extract of Celastrus paniculatus Willd. Whole plant has reduced the onset of Phenobarbitone-induced sleeping time in mice and prolonged the duration of sleeping time significantly (pCelastrus paniculatus Willd. Whole plant, using Staircase test model, it was revealed that the extract at doses 200 mg/kg and 400mg/kg reduced the number of rearings and decreased the number of steps ascended significantly (pCelastrus paniculatus Willd. whole plant contains some active principles which may possess significant CNS depressant and anxiolytic activity.

Keywords


Celastrus paniculatus Willd., CNS Depressant, Anxiolytic, Potentiation of Phenobarbitone-Induced Sleeping Time, Staircase Test.

References