Research Journal of Pharmacology and Pharmacodynamics

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Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole Plant in Mice


Affiliations
1 Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
2 GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
     

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The objective of the present study was to investigate the CNS depressant and Anxiolytic activity of the methanolic extract of the whole plant of Celastrus paniculatus Willd. (Family: Celastraceae) in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract (200 mg/kg, 400mg/kg and 600 mg/kg) on the central nervous system (CNS) was evaluated for potentiation of phenobarbitone-induced sleeping time in mice. The results revealed that the methanolic extract of Celastrus paniculatus Willd. Whole plant has reduced the onset of Phenobarbitone-induced sleeping time in mice and prolonged the duration of sleeping time significantly (pCelastrus paniculatus Willd. Whole plant, using Staircase test model, it was revealed that the extract at doses 200 mg/kg and 400mg/kg reduced the number of rearings and decreased the number of steps ascended significantly (pCelastrus paniculatus Willd. whole plant contains some active principles which may possess significant CNS depressant and anxiolytic activity.

Keywords

Celastrus paniculatus Willd., CNS Depressant, Anxiolytic, Potentiation of Phenobarbitone-Induced Sleeping Time, Staircase Test.
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  • Muller U, Fletcher PC, Steinberg H. The origin of Psychopharmacology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg(1882-1892). Psychopharmacology. 184(2); 2006:131-138.

  • Hamilton L.W and Timmons C.R. Psychopharmacology. In Encyclopedia of Psychology. London: Routlege press. 1;1994: 133-152.

  • Thase M.E and Howland. Biological processes in depression: An updated review and integration. In: Beckham EE and Leber WR. eds. Handbook of depression. Guilford Press, New York. 1995; 2nd ed: pp. 213-279.

  • Sinclair L and Nutt D. Anxiolytics. Psychiatry. 6(7);2007:284-8.

  • Goodman and Gilman. The pharmacological basis of therapeutics. McGraw-Hill, New York. 2001;10th ed: 447-448.

  • Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. Journal of Ethnopharmacology. 83(1-2); 2002:161-5.

  • Cragg GM, D.J Newman and K.M Snader. Natural products in drug discovery and development. Journal of Natural Products. 60(1); 1997:52-60.

  • Marin-Bettulo G.B. Present aspects of the use of medicinal plants in traditional medicine. Journal of Ethnopharmacology. 2(1);1980:5-7.

  • Nadkarni A.K. Indian Materia Medica. Popular prakashan, Bombay. 1(3); 1976:296.

  • Vaidyaratnam PSV. Indian Medicinal Plants: A Compendium of 500 species, Orient Longman Ltd., Madras. 2(1); 1997:47-51.

  • Sastry JLN, Chunekar KC. Dravyaguna Vijnana. Choukhamba, Orientalia, Varanasi. 2008; 3rd ed: pp. 128-131.

  • Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulate for analgesic and anti-inflammatory activities. Journal of Ethnopharmacology. 42(3); 1994:193-198.

  • Parcha V, Gahlot M, Tomar Y, Ram V. Studies on physicchemical properties, anti-inflammatory and antimicrobial activity of Celastrus paniculatus seed oil. Indian Journal of Natural Products. 19(2); 2003 : 21-23.

  • Patil KS, Suryavanshi J. Effect of Celastrus paniculatus Willd. seed on adjuvant induced arthritis in rats. Pharmacognosy Magazine. 3(11);2007:177-181.

  • Wangoo D, Bidwai PP. Antispermatogenic effect of Celastrus paniculatus seed extract on the testis of albino rats. Fitoterapia. 59; 1998: 377-382.

  • Harish BG, Krishna V, Santosh Kumar HS, Khadeer Ahmad BM et al. Wound healing activity and docking of glycogensynthatase- kinase-3-beta-protein with isolated triterpenoid lupeol in rats. Phytomedicine. 15(9); 2008: 763-767.

  • Pavanandt K, Kyle Webster H, Yongvanitchit K, Kun-anake A, Dechatiwonse T et al. Schizontocidal activity of Celastrus paniculatus Willd. against Plasmodium falciparum in vitro. Phytotherapy Research. 3(4); 1989: 136-139.

  • Patel RP, Trivedi BM. The in vitro antibacterial activity of some medicinal oils. Indian Journal of Medical Research. 50; 1962: 218-222.

  • Somanandhan B, Varughese G, Palpu S, Sreedharan R, Gudiksen L, Smitt UV, Nyman U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitiors from Indian medicinal plants. Journal of Ethnopharmacology. 65(2); 1999: 103-112.

  • Godkar P, Gordan RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide induced oxidative injury. Fitoterapia. 74(7-8); 2003: 658-669.

  • Godkar P, Gordan RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate- induced injury in embryonic rat forebrain neuronal cells. Phytomedicine. 13(1-2); 2006:29-36.

  • Mathur NT, Varma M, Dixit VP. Hypolipidaemic and antiatherosclerotic effect of Celastrus paniculatus seed extract in cholesterol fed rabbits. Indian Drugs. 30(2); 1993: 76-82.

  • Trease GE, Evans WC. Pharmacognosy. ELSB, Baillire Tindal, London. 14th ed, 1996.

  • Miy TS, HGO Holck, GKW Yui and GR Spratto. Laboratoty Guide in Pharmacology. Burgess Publishing Company, Minneapolis MN. 1973 :pp. 44-46.

  • Fujimori H. Potentiation of barbitual hypnosis as an evaluation method for central nervous system depressants. Psychopharmacology. 7(5);1965: 374-8.

  • Soulimani RC, Younos S, Jarmouni-Idrissi D, Bousta F, Khalouki and Laila A. Behavioral and pharmaco-toxicological study of Papaver rhoeas L. in mice. Journal of Ethnopharmacology. 74(3); 2001:265-274.

  • Turner RA. Depressants of the central nervous system. In Truner RA (Ed). Screening methods in pharmacology, Academic Press, New York and London. 1965: pp.69-86.

  • Mineur YS, Belzung C, Crusio WE. Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice. Behavioural Brain Research. 175(1); 2006: 43-50.

  • Rakotonirina VS, Bum EN, Rakotonirina A, Bopelet M. Sedative properties of the decoction of the rhizome of Cyperus articulatus. Fitoterapia. 72(1); 2001:22-9.

  • Tripathi KA. Essentials of medicinal pharmacology. Jaypee Brothers Medical Publishers, New Delhi. 1999.

  • Awe SO, Olajide OA, Adeboye JO, Makinde JM. Some pharmacological studies on Morinda lucida. Indian Journal of Pharmacology. 30(1);1998:38-42.

  • Deborah A, Gries, George A, Condouris, Shey Z, Houpt M. Anxiolytic-like action in mice treated with nitrous oxide and oral triazolam or diazepam. Life Sciences. 76(15); 2005: 1667- 1674.


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  • Psychopharmacological Screening of Methanolic Extract of Celastrus paniculatus Willd. whole Plant in Mice

Abstract Views: 347  |  PDF Views: 2

Authors

Diana Vivian Atigari
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
Sunanda Sabbithi
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
B. Krishna Chaitanya
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet) Secunderabad 500014, Andhra Pradesh, India
A. Jajisree
GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
C. Ramesh
GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India

Abstract


The objective of the present study was to investigate the CNS depressant and Anxiolytic activity of the methanolic extract of the whole plant of Celastrus paniculatus Willd. (Family: Celastraceae) in mice as a part of psychopharmacological screening of this plant, using different in vivo experimental models. The effects of the plant extract (200 mg/kg, 400mg/kg and 600 mg/kg) on the central nervous system (CNS) was evaluated for potentiation of phenobarbitone-induced sleeping time in mice. The results revealed that the methanolic extract of Celastrus paniculatus Willd. Whole plant has reduced the onset of Phenobarbitone-induced sleeping time in mice and prolonged the duration of sleeping time significantly (pCelastrus paniculatus Willd. Whole plant, using Staircase test model, it was revealed that the extract at doses 200 mg/kg and 400mg/kg reduced the number of rearings and decreased the number of steps ascended significantly (pCelastrus paniculatus Willd. whole plant contains some active principles which may possess significant CNS depressant and anxiolytic activity.

Keywords


Celastrus paniculatus Willd., CNS Depressant, Anxiolytic, Potentiation of Phenobarbitone-Induced Sleeping Time, Staircase Test.

References