Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Anti-obesity Activity of Lantana Camara Var Linn on Butter Induced Hyperlipidemia in Rats


Affiliations
1 Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Hyderabad-500060, A.P., India
2 Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (post via Hakimpet), Secunderabad (500014) AP, India
3 GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India
     

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The hypolipidemic activity of Lantana camara was studied on high fat diet induced models of hyperlipedemia in rats. Hyper lipidemia condition established by butter was evidenced by enhancement in levels of cholesterol, tri-glycerides, LDL, VLDL. Methanolic extract showed significant hypolipidemic effect by lowering of serum levels of serum cholesterol, TG, LDL, VLDL and increased dl level. Ethanobotanical knowledge of medicinal plants is some of the most prominent source of new drugs and has shown potential results for treatment of obesity. Prelimnary phytochemical analysis revealed thye presence of phyto constituents such as steroids, flavinoids, alkaloids.

Keywords

High Fat Diet, Lantana Camara, Obesity.
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  • Evaluation of Anti-obesity Activity of Lantana Camara Var Linn on Butter Induced Hyperlipidemia in Rats

Abstract Views: 306  |  PDF Views: 0

Authors

Rohit Gundamaraju
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Hyderabad-500060, A.P., India
Diana Vivian Atigari
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (post via Hakimpet), Secunderabad (500014) AP, India
D. S. Helen Sheeba
Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (post via Hakimpet), Secunderabad (500014) AP, India
C. Ramesh
GSN Pharmaceuticals Pvt. Ltd., Rajeev Gandhi Nagar, Kukatpally, Hyderabad (500072), AP, India

Abstract


The hypolipidemic activity of Lantana camara was studied on high fat diet induced models of hyperlipedemia in rats. Hyper lipidemia condition established by butter was evidenced by enhancement in levels of cholesterol, tri-glycerides, LDL, VLDL. Methanolic extract showed significant hypolipidemic effect by lowering of serum levels of serum cholesterol, TG, LDL, VLDL and increased dl level. Ethanobotanical knowledge of medicinal plants is some of the most prominent source of new drugs and has shown potential results for treatment of obesity. Prelimnary phytochemical analysis revealed thye presence of phyto constituents such as steroids, flavinoids, alkaloids.

Keywords


High Fat Diet, Lantana Camara, Obesity.

References