Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Extraction and Screening of Antioxidant, Anti-Inflammatory and Analgesic Activity of Rhynchosia Beddomel Leaves


Affiliations
1 Dept of Pharmacology, Dayananda Sagar College of Pharmacy, Shavige Malleshwara Hills, Kumarswamy Layout, Bangalore-560078, India
2 Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India
     

   Subscribe/Renew Journal


The use of traditional medicine is expanding to newer horizons and plants still remain as the novel source of structurally important compounds that lead to the development of innovative drugs. India has about 45,000 plant species among which medicinal property has been attributed to several thousands. The traditional Indian system of medicine, the Ayurveda, mentions the use of plants in the treatment of various diseased conditions. Ethno botanical research done in last few decades have revealed the anti-inflammatory and anti-oxidant properties of plants cited in the traditional literature. Many herbal preparations are being prescribed as anti-inflammatory and antioxidant in the traditional literature. The search for new anti-inflammatory and analgesic agents from the huge array of medicinal plant resources is intensifying. This is because such plants may hold assurance for the discovery of novel therapeutic agents capable of suppressing, reducing or relieving pain as well as inflammation. This chapter reviews such plant species and their products that have shown experimental antioxidant, antiinflammatory and analgesic activities.

Keywords

Ayurveda, Anti-Inflammatory, Analgesic.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Anonymous. Sectoral Study an Indian Medicinal Plants- status, perspective and strategy for growth. Biotech Consortium India Ltd., New Delhi. 1996.

  • The biome News In: Arora JR, Swarup R and Gupta SV (eds.); Vol 1 (2). Dept of Biotechnology, Ministry of Science and Technology, Govt of India.

  • Nikhitha, Mathangi AE, Chinna M, Eswaraiah, Azmeera, Mamatha, Swathi, Areefa Shaik. An updated analgesic review on medicinal plants; IJPRD, 2011; 4(1):22-29.

  • Vani T, Rajani M, Sarkar S and Shishoo CJ. Antioxidant properties of the Ayurvedic formulation Triphala and its constituents. Int. J. Pharmacog; 35,1997:313-317.

  • Ravishankara MN, Shrivastava N, Padh H and Rajani M. Evaluation of antioxidant properties of ischolar_main bark of Hemidesmus indicus. Phytomedicine; 2002 9: 153-160.

  • Bagul MS, Ravishankara MN, Padh H and Rajani M. Phytochemical evaluation and Free radical scavenging properties of rhizome of Bergenia ciliata (Haw) Sternb. J.nat Rem; 2003: 3: 83-89.

  • Nishimiki M, Rao NA, Appaji N and Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochemical and Biophysical Res. Communica; 1972: 46: 849-854.

  • Dixon WJ and Mood AM. A method for obtaining and analyzing sensitivity data. Amer statist Assoc ; 1948: 43:109- 126.

  • Serhan CN and Savil J. Resolution of inflammation. Nature Immunol; 2005: 6:1191-1197.

  • Winter CA, Risely EA and Nuss GW Carrageenan induced oedema in hind paw of the rat as assay for anti-inflammatory drugs. Pro. Soc. Exp. Biol. Med; 1962: 111:544-547.

  • Tubaro A, Dri P, Delbello, G, Zilli C, Delia Loggia R. The croton oil ear test revisited. Agents Actions :1985:17, 347-349.

  • Coleman JW. Nitric oxide a regulator of mast cell activation and mast cell mediated inflammation. Clin. Exp. Immunol: 2002: 129: 4-10.

  • Slater TF. Free-radical mechanisms in tissue injury,. Biochem J; 1984: 222: 1-15.

  • Larrauri JA, Sanchez-Moreno C, Ruperez P and Saura-Calixto F. Free radical scavenging capacity in the aging of selected red Spanish wines. J. Agric. Food Chem:1999:47: 1603-1606.

  • Yen GC and Wu JV. Antioxidant and radical scavenging properties of extracts from Ganoderma tsugae. Food Chem; 1999: 65: 375-379.

  • Wasim Ahmed, Zaheer Ahmad and Abdul Malik. Stigmasteryl Galactoside from Rhynchosia minima,. Phytochemistry; 1992 vol.31.no11, pp4038-4039.

  • Gunasekar, Pasupulati Ramachandraiah, Otto Seligmann,Hildbert WagnerTirumalin a new prenylated dihydroflavonol from Rhynchosia Cyanosperma. Phytochemistry; 1980:19:478-480.

  • Dama,Adinarayana,Duvuru,Gunasekar,Pasupulati Ramachandraiah, Otto Seligmann, Hildbert Wagner. Tirumalin a new prenylated dihydroflavonol from Rhynchosia Cyanosperma. Phytochemistry; 1980:19:478-480

  • Soon YYand Tan BK. Evaluation of the hypoglycemic and antioxidant activities of Morinda officinalis in streptozotocininduced diabetic rats. Singapore Med. J; 2002: 43(2): 077-085.

  • Iwalewa E, Mc Gaw LJ, Naidoo V, Eloff JN. Inflammation: the foundation of diseases and disorder. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. African Journal Biotechnology; 2007: 6(25): 2868-2885.

  • Brito ARMS and Antonio MA. Oral anti-inflammatory and antiulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J. Ethnopharmacol; 1998:61: 215-228.

  • Castro JA, De Ferreyra EC and De Castro CR. Prevention of carbotetrachloride induced necrosis by inhibitors of drug metabolism-further studies on their mechanism of action. Biochem Pharmacol; 1974: 23:295-302.

  • Beatriz B, Gerardo M, Antonio JL and Jose ASE. Anti-inflammatory Activity of Urera baccifera (Urticaceae) in Sprague Dawley Rats. Rev. Biol. Trop; 1999: 47(3): 365-71.

  • Di rosa M. Biological properties of carrageenan. J. Pharm. Pharmacol; 1972: 24: 89-102.

  • Kumar VL and Arya S. Medicinal uses and pharmacological properties of Calotropis procera Recent Prog. Med. Plants; S11: 2006: 373-388.

  • Hinz B, Brune K, Pahl A. Cyclooxygenese-2 expression in lipipolysaccharide-stimulated human monocytes is modulated by cyclic Amp, Prostaglandin(2) and nonsteroidal anti-inflammatory drugs. Biochem. Biophys. Res. Commun; 2000: 278: 790.

  • Ueno A, Oh-ishi S. Critical roles for bradykinin and prostanoids in acute inflammatory reactions: a search using experimental animal models,. Curr.Drug.Targets inflamm .Alergy; 2002: 1(4):363-376.

  • Vinegar R, Schreiber, W and Hugo, R. Biphasic development of carrageenin edema in rats. J. Pharmocol.Exp.Therapeutics; 1968: 166(1):96-103.

  • Ku E, Scholer D, Boettcher I, Schweizer A. Pharmacology of diclofenac sodium*1,*2. The American. J. Med; 1976,80(4):34-38.

  • Watt JM, Breyer-Brandwijk MG. The medicinal and poisons plants of Southern and Eastern Africa. E&S Livingston Ltd., Edinburgh London. 1962.


Abstract Views: 274

PDF Views: 0




  • Extraction and Screening of Antioxidant, Anti-Inflammatory and Analgesic Activity of Rhynchosia Beddomel Leaves

Abstract Views: 274  |  PDF Views: 0

Authors

N. B. Sridharamurthy
Dept of Pharmacology, Dayananda Sagar College of Pharmacy, Shavige Malleshwara Hills, Kumarswamy Layout, Bangalore-560078, India
Dhiman Vinay
Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India
R. Yogananda
Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India

Abstract


The use of traditional medicine is expanding to newer horizons and plants still remain as the novel source of structurally important compounds that lead to the development of innovative drugs. India has about 45,000 plant species among which medicinal property has been attributed to several thousands. The traditional Indian system of medicine, the Ayurveda, mentions the use of plants in the treatment of various diseased conditions. Ethno botanical research done in last few decades have revealed the anti-inflammatory and anti-oxidant properties of plants cited in the traditional literature. Many herbal preparations are being prescribed as anti-inflammatory and antioxidant in the traditional literature. The search for new anti-inflammatory and analgesic agents from the huge array of medicinal plant resources is intensifying. This is because such plants may hold assurance for the discovery of novel therapeutic agents capable of suppressing, reducing or relieving pain as well as inflammation. This chapter reviews such plant species and their products that have shown experimental antioxidant, antiinflammatory and analgesic activities.

Keywords


Ayurveda, Anti-Inflammatory, Analgesic.

References