Research Journal of Pharmacology and Pharmacodynamics

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Asthma and Plants Used for Asthma - An Overview


Affiliations
1 Claris Life Sciences Ltd., Ahmadabad, Gujarat, India
2 Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, India
3 Rofel College of Pharmacy, Vapi, Gujarat, India
     

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Asthma is best described as a chronic disease that involves inflammation of the pulmonary airways and bronchial hyperresponsiveness that results in the clinical expression of a lower airway obstruction that usually is reversible. Physiologically, bronchial hyperresponsiveness is documented by decreased bronchial airflow after bronchoprovocation with methacholine or histamine. Other triggers that provoke airway obstruction include cold air, exercise, viral upper respiratory infection, cigarette smoke, and respiratory allergens. Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availability of a wide range of drugs for the treatment of asthma, the relief offered by them is mainly symptomatic and short lived. Moreover the side effects of these drugs are also quite disturbing. Medicinal Plants have been the highly esteemed source of medicine throughout human history. They are widely used today indicating that they are a growing part of modern, hightech medicine. About 25-30 percent of today's prescription drugs contain chemical moieties derived from plants. The Indian system of medicine i.e Ayurveda alongwith classic texts like Bheshajya Ratnavali has a longstanding tradition that offers a unique insight into comprehensive approach to asthma management through proper care of the respiratory tract. Ayurvedic formulations used in the management of asthma, therefore, judiciously combine herbs to support the physiology of respiration, these herbs apart from exerting bronchial action also possess concomitant properties like antioxidant to support the digestive, cardiac, nerve functions and expectorant as well as just plain soothing herbs. In the present article an attempt has been made to review antiasthmatic medicinal plants with their active chemical constituent and possible mechanism of action.

Keywords

Asthma, Symptomatic, Respiration, Bronchospasm, Airways.
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  • National Heart, Lung,and Blood Institute, National Asthma Education and Prevention Program. Expert Panel Report 3:Guidelines for the Diagnosis and Management of Asthma: Full Report 2007. Bethesda, Md: NHLBI; August 2007. Publication no. 07-4051. [Full Text].

  • Anderson SD. How does exercise cause asthma attacks?. Curr Opin Allergy Clin Immunol. Feb 2006;6(1):37-42. [Medline].

  • Hough DO, Dec KL. Exercise-induced asthma and anaphylaxis. Sports Med. Sep 1994;18(3):162-72. [Medline].

  • Beaudouin E, Renaudin JM, Morisset M, et al. Food-dependent exercise-induced anaphylaxis - update and current data. Allerg Immunol (Paris). Feb 2006;38(2):45-51. [Medline].

  • Stensrud T, Berntsen S, Carlsen KH. Exercise capacity and exercise-induced bronchoconstriction (EIB) in a cold environment. Respir Med. Jul 2007;101(7):1529-36. [Medline]

  • Tarek S. Towards a deep understanding of bronchial asthma. Egyptian Journal of Bronchology, 2007 Dec; 1(1): 120-124.

  • Global Initiative for Asthma, Global Strategy for Asthma Management and Prevention, NIH Publication no. 02-3659, National Institutes of Health/National Heart, Lung and Blood Institute, Bethesda, Md, USA, 2005.

  • Busse WW, Calhoun WJ, Sedgwick JD. Mechanisms of airway inflammation in asthma. Am. Rev. Respir. Dis. 147:S20-S24.

  • Doshi U, Salat P, Parikh V. Cytokine modulators in Asthma: clinical perspectives. Indian J pharmacol 2002; 34: 16-25.

  • Goswami DV, Sonawane LL, Nirmal SA, Patil MJ. Evaluation of antiasthmatic activity of tectona grandis linn. Bark. Int J Pharm. Sci. and Res.2010;1(1):10-16.

  • M.Masoli, D. Fabian, S. Holt, and R. Beasley, "The global burden of asthma: executive summary of the GINA Dissemination Committee report," Allergy, vol. 59, no. 5, pp. 469-478, 2004.

  • Christopher EB, Peter B, Fiona AS, Stephen TH, Andrew J W, Ian DP. Mast-cell infiltration of airway smooth muscle in asthma. New Eng J Med 2002; 33; 1699-1705.

  • Gregory GK, Peter DP, Chun YS. The mechanics of exaggerated airway narrowing in asthma the role of smooth muscle. Respiration Physiology 1999; 118:1-13.

  • Sundeep SS, Mamudipudi TK, Anthony PS, Stephen TH. The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma. Chest 2001; 119:1533-1546.

  • Wardlaw AJ, Brightling CE, Green R, Woltmann G, Bradding P, Pavord ID. New insights into the relationship between airway inflammation and asthma. Clinical Science 2002; 103: 201-211.

  • B. T. Kitch, B. D. Levy, and C. H. Fanta, "Late onset asthma: epidemiology, diagnosis and treatment," Drugs and Aging, vol. 17, no. 5, pp. 385-397, 2000.

  • B. A. Bauer, C. E. Reed, J. W. Yunginger, P. C. Wollan, and M. D. Silverstein, "Incidence and outcomes of asthma in the elderly," Chest, vol. 111, no. 2, pp. 303-310, 1997.

  • P.Weiner, R.Magadle, J.Waizman, M.Weiner, M. Rabner, and D. Zamir, "Characteristics of asthma in the elderly," European Respiratory Journal, vol. 12, no. 3, pp. 564-568, 1998.

  • P. L. Enright, R. L. McClelland, A. B. Newman, D. J. Gottlieb, and M. D. Lebowitz, "Underdiagnosis and undertreatment of asthma in the elderly. Cardiovascular Health Study Research Group," Chest, vol. 116, no. 3, pp. 603-613, 1999.

  • P. L. Enright, "The diagnosis and management of asthma is much tougher in older patients," Current Opinion in Allergy and Clinical Immunology, vol. 2, no. 3, pp. 175-181, 2002.

  • J. E. Moorman and D. M. Mannino, "Increasing US asthma mortality rate who is really dying?" Journal of Asthma, vol. 38, pp. 65-70, 2001.

  • L. Dow, D. Coggon, M. J. Campbell, C. Osmond, and S. T. Holgate, "The interaction between immunoglobulin E and smoking in airflow obstruction in the elderly," American Review of Respiratory Disease, vol. 146, no. 2, pp. 402-407, 1992.

  • M. J. Connolly, J. J. Crowley, N. B. Charan, C. P. Nielson, and R. E. Vestal, "Reduced subjective awareness of bronchoconstriction provoked by methacholine in elderly asthmatic and normal subjects as measured on a simple awareness scale," Thorax, vol. 47, no. 6, pp. 410-413, 1992.

  • C. S. Ulrik and P. Lange, "Decline of lung function in adults with bronchial asthma," American Journal of Respiratory and Critical Care Medicine, vol. 150, no. 3, pp. 629-634, 1994.

  • Yawn, BP (September 2008). "Factors accounting for asthma variability: achieving optimal symptom control for individual patients". Primary Care Respiratory Journal 17 (3): 138-147. doi:10.3132/pcrj.2008.00004. PMID 18264646.

  • Kumar, Vinay; Abbas, Abul K; Fausto, Nelson; Aster, Jon (2010). Robbins and Cotran Pathologic Basis of Disease (8th ed.). Saunders. p. 688. ISBN 978-1-4160-3121-5.

  • Moore WC, Pascual RM (June 2010). "Update in asthma 2009". American journal of respiratory and critical care medicine 181 (11): 1181-7. doi:10.1164/rccm.201003-0321UP. PMID 205 16492.

  • Self, Timothy. Chrisman,Cary. Finch, Christopher. "Applied Therapeutics: The Clinical Use of Drugs, 9th Edition" Philadelphia: Lippincott Williams&Wilkins, 2009. Chapter 22 (Asthma)

  • Delacourt, C (June 2004). "Bronchial changes in untreated asthma". Archives de Pediatrie 11 (Suppl. 2): 71s-73s. PMID 15301800.

  • Schiffman, George (18 December 2009). "Chronic Obstructive Pulmonary Disease". MedicineNet. Retrieved 2 September 2010.

  • National Heart, Lung,and Blood Institute, National Asthma Education and Prevention Program. Expert Panel Report 3:Guidelines for the Diagnosis and Management of Asthma: Full Report 2007. Bethesda, Md: NHLBI; August 2007. Publication no. 07-4051.

  • Anderson SD. How does exercise cause asthma attacks?. Curr Opin Allergy Clin Immunol. Feb 2006;6(1):37-42. [Medline].

  • Hough DO, Dec KL. Exercise-induced asthma and anaphylaxis. Sports Med. Sep 1994;18(3):162-72. [Medline].

  • Beaudouin E, Renaudin JM, Morisset M, et al. Food-dependent exercise-induced anaphylaxis - update and current data. Allerg Immunol (Paris). Feb 2006;38(2):45-51. [Medline].

  • "Fatal and Nonfatal Injuries, and Selected Illnesses and Conditions: Respiratory Diseases". Worker Health Chart book 2004. National Institute for Occupational Safety and Health. September 2004. Retrieved December 17, 2008.

  • "Asthma and Allergies". National Institute for Occupational Safety and Health. September 22, 2008. Retrieved March 23, 2009.

  • Salam MT, Islam T, Gilliland FD (January 2008). "Recent evidence for adverse effects of residential proximity to traffic sources on asthma". Curr Opin Pulm Med 14 (1): 3-8. doi:10.1097/MCP.0b013e3282f1987a. PMID 18043269.

  • Liu AH (2004). "Something old, something new: indoor endotoxin, allergens and asthma". Paediatr Respir Rev 5 (Suppl A): S65-71. doi:10.1016/S1526-0542(04)90013-9. PMID 14980246.

  • Dales R, Raizenne M (2004). "Residential exposure to volatile organic compounds and asthma". J Asthma 41 (3): 259-70. doi:10.1081/JAS-120026082. PMID 15260458.

  • Sharma A, Shanker C, Tyagi L, Singh M, Rao CV. Herbal medicine for market potential in India: An Overview. Academic Journal of Plant Sciences. 2008; 1(2): 26-36.

  • Rastogi RP, Mehrotra BN, Compendium of indian medicinal plants, 1st Edition, Vol 3, CDRI Lucknow and PID New Delhi, 1980-1984; 10, 224, 294, 376.

  • Chaudhari RD (Ed.). Pharmacological classification of medicinal herbs, Herbal Drug industry, Eastern Publishers, New Delhi, 1st Edition, 2004; 61.

  • Paliwa JK, Dwiwedi AK, Singh S. Pharmacokinetics and in-situ absorption studies of a new antiallergic compound 73/602 in rats, Int. J. Pharm. 2000;197(1-2): 213-220

  • Evans WC. Trease and Evans Pharmacognosy, 15th edn, WB Saunders Company Ltd., London, 2003; 299, 471, 485

  • Tripathi RM, Das PK. Studies on antiasthmatic and anti anaphylactic activity of Albizzia lebbeck Ind. J. Pharmacol 1977, 9(3):189-194

  • Tripathi RM, Sen PC, Das PK Studies on the mechanismof action of Albizzia lebbeck, an indigenous drug used in the treatment of atopic allergy, J Ethnopharmacol.1979,1, 1385- 1396.

  • Raju D, Chitra V, Hari Das K, Silambu Janiki P, Shankari M. Evaluation of antiasthmatic activity of aqueous extract of Achillea mellifolium linn flowers. Arc. Apl. Sci. Res., 2009 1(2): 287-293

  • Akah PA, Ezike AC, Nwafr SV, Okoli CO, Enwerem NM. Evaluation of the antiasthmatic property of Asystasia gangetica leaf extracts. J Ethnopharmacol. 2003 (89):25-36.

  • Gupta I, Gupta V, Parihar A, Gupta S, Ludtke R, Safeyhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebocontrolled 6 week clinical study. Eur. J. Med. Res. 1998; (11): 511-514.

  • Singh V, Tripathi P, Patel JR, Kori ML, Dixit VK, Preliminary phytochemical and antiasthmatic studies on stem bark of Balanites roxburghii planch. International Journal of Pharmaceutical and Clinical Research 2009,1(1):40-42 .

  • Shinde UA, Phadke AS, Kulkarni KR, Nair AM, Mungantiwar AA, Dixit VJ, Saraf MN Mast cell stabilizing and lipoxygenase inhibiting activity of Cedrus deodara(Roxb.) wood oil. Indian J.Exp.Biol. 1999; 37(3): 258-261.

  • Pandit P, Singh A, Bafna AR, Kadam PV, Patil MJ. Evaluation of antiasthmatic activity of Curculigo orchioides Gaertn. Rhizomes. Ind J Pharm Sci. 2008 July-August; 440-444

  • Vadnere GP, Somani RS, Singhai AK. Studies on antiasthmatic activity of aqueous extract of Clerodendron phlomidis. Pharmacologyonline. 2007(1) :487-494

  • Ammon HP, Wahl MA. Pharmacology of curcuma longa. Planta Medica 1991,57(1), 1-7

  • Nagore DH, Ghosh VK, Patil MJ. Evaluation of antiasthmatic activity of Cassia sophera Linn. Pharmacognosy magazine. 2009; 5(19):109-118

  • Wu JB, Chun YT, Ebizuka Y, Sankawa V. Biologically active constituents of Centipeda minima: isolation of a new phenolin ester and the antiallergic activity of sesquiterpene lactones. Chem. Pharm. Bull.1985,33: 4091-4094 .

  • Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants, 1st Edition, Vol 4, CDRI Lucknow and PID New Delhi, 1985-1989; 154, 246, 288, 315, 348, 360.

  • Focho DA, Nkeng EAP, Fonge BA, Fongod AN, Muh CN, Ndam TW, Afegenui A. Diversity of plants used to treat respiratory diseases in Tubah, northwest region, Cameroon. African J. of Pharm. Pharmacol. 2009 Nov3(11): 573-580.

  • Arul V, Miyazaki A, Dhananjayan R. Mechanism of the contractile effect of the alcoholic extract of Aegle marmelos corr. on isolated guinea pig ileum and tracheal chain. Phytomedicine. 11(7): 679-683.

  • Chaturvedi GN, Sharma BD. Ethnobotnical survey of the plants used to treat asthma in Andhra Pradesh. Journal of research in Indian medicine. 1975;10(2):6

  • Shekhar AV, Gandhi DN, Mohan Rao N, Rawal UD. An experimental and clinical evaluation of Antiasthmatic potentialities of Devadaru compound (Dc) Indian J Physiol Pharmacol. 2003 Jan.47(1): 101-107 .

  • RP Rastogi, BN Mehrotra. Compendium of Indian Medicinal Plants, 1st Edition, Vol 4, CDRI Lucknow and PID New Delhi, 1985-1989; 154, 246, 288, 315, 348, 360.

  • WC Evans. Trease and Evans Pharmacognosy, 15th edn, WB Saunders Company Ltd., London, 2003; 299, 471, 485.

  • Srivastava S, Gupta PP, Prasad R, Dixit KS, Palit G, Ali B, Misra G, Saxsena RC. Evaluation of antiallergic activity (type I hypersensitivity) of Innula racemosa in rats. Indian J. Physiol. Pharmacol. 1999;29,89-95.

  • Agrawal B, Mehta A. Antiasthmatic activity of Moringa olifera Lam: A clinical study Indian J Pharmacol. 2009; 40(1): 28-31

  • Patel KG, Bhalodia PN, Patel AD, Patel KV, Gandhi TR. Evaluation of bronchodilator anti anaphylactic activity of Myrica sapida. Iranian Biomedical Journal .2008;12 (3):191- 196.

  • Doshi VB, Shetge VM, Mahashur AA, Kamat SR, Picrorrhiza kurroa in bronchial asthma. J. Postgrad. Med.1983;29:89-95.

  • Mali RG, Mahajan SG, Mehta AA. Studies on bronchodilatory effect of Lepidium sativum against allergen induced bronchospasm in guinea pigs. Pharmacognosy magazine. 2008; 4(15) :189-192 .

  • Dhawan K, Kumar S, Sharma A. antiasthmatic activity of the Methanol extract of leaves of Passiflora incarnata.Phytother.Res.2003;17:821-22 .

  • Vadnere GP, Gaud RS, Singhai AK. Evaluation of antiasthmatic property of Solanum xanthocarpum flowers extracts. Pharmacologyonline. 2008;1: 513-522 .

  • Govindan S, Vishwanathan S, Vijaysekaran V, Alagappan R, A pilot study on the clinical efficacy of Solanum xanthocarpum and solanum trilobatum in bronchial asthma. J Ethnopharmacol. 1999;66: 205-210 .

  • Vyas BA, Vyas RB. Effect of ethanolic extracts of Allium sativum and Terminalia belerica on clonidine induced mast cell degranulation and clonidine and haloperidol induced catalepsy in mice. Int J Pharm Res 2009; 1(1) : 41-44 .

  • Nayampalli SS, Desai NK, Ainapure SS.Antiallergic properties of Tinspora cordifolia in animal models. Indian J. Pharmacol. 1986;18:250-252.

  • Tayade PM, Ghaisas MM, Jagtap SA, Dongre SH. Antiasthmatic activity of methanolic extract of leaves of Tamarandus indica linn. Journal of pharmacy research.2009, 2(5):944-947.


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  • Asthma and Plants Used for Asthma - An Overview

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Authors

Vipul Shah
Claris Life Sciences Ltd., Ahmadabad, Gujarat, India
Vrunda Shah
Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, India
D. D. Santani
Rofel College of Pharmacy, Vapi, Gujarat, India

Abstract


Asthma is best described as a chronic disease that involves inflammation of the pulmonary airways and bronchial hyperresponsiveness that results in the clinical expression of a lower airway obstruction that usually is reversible. Physiologically, bronchial hyperresponsiveness is documented by decreased bronchial airflow after bronchoprovocation with methacholine or histamine. Other triggers that provoke airway obstruction include cold air, exercise, viral upper respiratory infection, cigarette smoke, and respiratory allergens. Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availability of a wide range of drugs for the treatment of asthma, the relief offered by them is mainly symptomatic and short lived. Moreover the side effects of these drugs are also quite disturbing. Medicinal Plants have been the highly esteemed source of medicine throughout human history. They are widely used today indicating that they are a growing part of modern, hightech medicine. About 25-30 percent of today's prescription drugs contain chemical moieties derived from plants. The Indian system of medicine i.e Ayurveda alongwith classic texts like Bheshajya Ratnavali has a longstanding tradition that offers a unique insight into comprehensive approach to asthma management through proper care of the respiratory tract. Ayurvedic formulations used in the management of asthma, therefore, judiciously combine herbs to support the physiology of respiration, these herbs apart from exerting bronchial action also possess concomitant properties like antioxidant to support the digestive, cardiac, nerve functions and expectorant as well as just plain soothing herbs. In the present article an attempt has been made to review antiasthmatic medicinal plants with their active chemical constituent and possible mechanism of action.

Keywords


Asthma, Symptomatic, Respiration, Bronchospasm, Airways.

References