Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

An Ebola: Overview


Affiliations
1 Department of Quality Assurance Technique, P.D.V.V.P.F'S College of Pharmacy, Ahmednagar, India
2 H.S.B.P.V.T. College of Pharmacy, Kashti Tal. Shrigonda, Ahmednagar, India
     

   Subscribe/Renew Journal


Ebola hemorrhagic fever (Ebola HF) is a severe, often-fatal disease in humans and nonhuman primates (monkeys and chimpanzees) that has appeared sporadically since its initial recognition in 1976.Most species of ebolavirus and the only known species of virus occur in Africa. Primates are infected sporadically from an unknown source; current evidence suggests that the reservoir hosts are probably bats. Humans seem to become infected directly from bats in caves, as well as when they contact tissues from infected apes and other species. Once the virus has entered the population, it can spread from person to person. Some epidemics affect hundreds of people and decimate entire villages, particularly where hospital facilities and medical supplies are inadequate and nosocomial spread occurs. Although the mortality rate varies, the most pathogenic viruses kill up to 90% of those who become infected. No vaccine is available, and the only treatment is supportive.

Keywords

Ebola Virus Disease, Haemorrhagic Fever, Ebola Virus Outbreak.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Peters CJ, Le Duc JW. An introduction to Ebola: the virus and the disease. J Infect Dis 1999; 179 (Suppl 1): ix-xvi.

  • World Health Organization (WHO) Media Center: Ebola virus disease. Fact sheet No. 103.

  • Leroy EM, Kumulungui B, Pourrut X, Rouquet P, Hassanin A, Yaba P, Delicat A, Paweska JT, Gonzalez JP, Swanepoel R. Fruit bats as reservoirs of Ebola virus. Nature 2005; 438:575-6.

  • Rodriguez LL, De Roo A, Guimard Y, Trappier SG, Sanchez A, Bressler D,Williams AJ, Rowe AK, Bertolli J Khan AS, Ksiazek TG, Peters CJ, Nichol ST. Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis 1999; 179 (Suppl 1):S170-6.

  • Bermejo M, Rodriguez- Teijeiro JD, Illera G, Barroso A, Vilà C, Walsh PD. Ebola outbreak killed 5000 gorillas. Science 2006; 314:1564.

  • Sanchez A, Geisbert CW, Feldman H. Filoviridae: Marburg and Ebola viruses. In: Knipe DM, Howley PM, editors. Fields virology, 5th ed. Philadelphia: Lippincott, Williams &Wilkins 2007. pp. 1409-48

  • Olsen SJ, Chang HL, Cheung TY, Tang AF, Fisk TL, et al. (2003) Transmission of the severe acute respiratory syndrome on aircraft. N Engl J Med 349: 2416- 2422.

  • European Centre for Disease Prevention and Control (ECDC) (2014) Updated 8 April. Outbreak of Ebola virus disease in West Africa. ECDC, Stockholm.

  • Centers for Disease Control and Prevention (CDC). Ebola haemorrhagic fevers. Outbreak of Ebola in Guinea and Liberia.

  • Lee, J.E.; Fusco, M.L.; Hessell, A.J.; Oswald, W.B.; Burton, D.R. and Saphire, E.O. (2008) Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 454:177-182.

  • Cacciotti I , Aspetti PC, Cenciarelli O, Carestia M, Di Giovanni D, et al. (2014) Simulation of Caesium-137 (137Cs) Local Diffusion as a Consequence of the Chernobyl Accident Using Hotspot. Defence S&T Technical Bullettin 7: 18-26.

  • European Commission, SANCO-Public Health Directorate, G4 Unit-Communicable, Rare and Emerging Diseases (2003) Measures undertajen by member states and accession countries to control the outbreak of SARS.

  • Cenciarelli O, Pietropaoli S, Frusteri L, Malizia A, Carestia M, et al. (2014) Biological Emergency Management: The Case of Ebola 2014 and the Air Transportation Involvement. J Microb Biochem Technol 6:247-253.doi:10.4172/1948-5948.100.


Abstract Views: 298

PDF Views: 0




  • An Ebola: Overview

Abstract Views: 298  |  PDF Views: 0

Authors

S. C. Dudhal
Department of Quality Assurance Technique, P.D.V.V.P.F'S College of Pharmacy, Ahmednagar, India
S. A. Hapse
Department of Quality Assurance Technique, P.D.V.V.P.F'S College of Pharmacy, Ahmednagar, India
M. B. Kothule
H.S.B.P.V.T. College of Pharmacy, Kashti Tal. Shrigonda, Ahmednagar, India

Abstract


Ebola hemorrhagic fever (Ebola HF) is a severe, often-fatal disease in humans and nonhuman primates (monkeys and chimpanzees) that has appeared sporadically since its initial recognition in 1976.Most species of ebolavirus and the only known species of virus occur in Africa. Primates are infected sporadically from an unknown source; current evidence suggests that the reservoir hosts are probably bats. Humans seem to become infected directly from bats in caves, as well as when they contact tissues from infected apes and other species. Once the virus has entered the population, it can spread from person to person. Some epidemics affect hundreds of people and decimate entire villages, particularly where hospital facilities and medical supplies are inadequate and nosocomial spread occurs. Although the mortality rate varies, the most pathogenic viruses kill up to 90% of those who become infected. No vaccine is available, and the only treatment is supportive.

Keywords


Ebola Virus Disease, Haemorrhagic Fever, Ebola Virus Outbreak.

References