Synthesis, Characterization and Anti-Microbial Evaluation of Substituted Benzo[g]indol-2-one Derivatives

Indole derivatives (Isatin) are potential synthons, for building synthetically a variety of chemical systems known for their broader biological and pharmacological applications. In the present investigation, title compounds (V1-V5) were synthesized by the condensation reaction of 3-[(2)-(phenyl methylidene) hydrazono]-1, 3-dihydro-2H-benzo[g]indol-2-one (IV) with different aryl aldehydes, as such reactions are not reported so far. The synthesized compounds were characterized by IR, ¹H NMR and MASS spectroscopy. They were screened for their antimicrobial potential against bacterial strains i.e., Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris and fungal strains i.e., Candida albicans and Yeast. Compound V5 (Nitro) was more potent anti- microbial agent against both bacteria [Gram (+Ve) and Gram (-Ve) organisms] followed by compound V₄ (Chloro) and V₂ (4-Methoxy).