Antidiabetic Activity of Psidium guajava (Guava) Leaves Extract

Psidium guajava leaves extracts were investigated for hypoglycemic activity. Aqueous extract and ethanolic extract of leaves were prepared and screened for hypoglycemic activity. Psidium guajava therapy not only produces blood glucose homeostasis but also reversed metabolic and pathologic changes that took place in pancreatic islets.β-cell secretary activity resumed near normal as evidenced electron microscopic studies. In diabetic albino rats, mean percentage reduction in blood glucose level was found to be 18.88 % and 9.19±% for ethanolic and aqueous extracts respectively. The effect was initiated from first day and increase simultaneously up to thirteenth day. The hypoglycemic effect of ethanolic extract was better compared to same dose of aqueous extract. Blood glucose monitoring and electron-microscopic studies proving that Psidium guajava manifests its beneficial activity through β-cell rejuvenation, regeneration and stimulation.