Research Journal of Science and Technology

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Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations


Affiliations
1 Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh -160036, India
     

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The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.

Keywords

Cosmetics, Pharmaceuticals, Personal Care Products, Parabens, GC-MS, Preservatives.
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  • Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations

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Authors

Atul Bajaj
Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh -160036, India
Cijo John
Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh -160036, India
Joydip Choudhury
Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh -160036, India
Rohitashva Mani Tripathi
Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh -160036, India

Abstract


The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.

Keywords


Cosmetics, Pharmaceuticals, Personal Care Products, Parabens, GC-MS, Preservatives.

References