Research Journal of Science and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis of N-Mannich Bases of some Substituted Carbazoles


Affiliations
1 Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India
2 Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh, India
     

   Subscribe/Renew Journal


Through reactions with numerous secondary amines and a series of aldehydes, including formaldehyde and acetaldehyde, novel carbazole derivative conjugates were created from carbazole. Corresponding analogues were identified through spectral studies, and they were tested for their ability to reduce pain and control seizures using the Eddy's Hot Plate method and the maximum electrical shock convinced convulsion method, respectively. Students created the statistical analysis using the "t" test, and the standards were stated as mean SEM.

Keywords

Mannich bases, Carbazole, Anti-nociceptive, Anti-epileptic.
Subscription Login to verify subscription
User
Notifications
Font Size


  • A. J. Waring, Comprehensive Organic Chemistry, Vol. 1, Pergamon Press, Oxford, (1997), p.1041.

  • C. Mannich and W. Krosche, Arch. Pharm., 250, 647 (1912).

  • K. J. Rajendra Prasad and C. Kavitha, Ind. J. Heterocyclic Chem., 12, (2003).

  • C. Biberger, T. Golob, G. Walter and E. Von Angerer, Arch. Pharm., 333 (9), 305-311, (2000).

  • V. V. Mulwad, M. B. Dalvi and B. S. Mahaddalkar, Ind. J. Chem., 7, 1477-1479, (2002).

  • Hua Yan, Tomoko Chiba, Yashihiro Kitamura Hideka Miura and Masayuki Fujino,Antivir. Chem. Chemother., 16 (6), 363-373, (2005).

  • Christina Aschea, Walter Frankb and Antje Albertb, Bio. Org. Med. Chem., 13 (3),817-837, (2005).

  • S. K. Kulkarni, Handbook of Experimental Pharmacology, 3rd Edn, Vallabh Prakashan, (1987) p. 125.

  • S. K. Kulkarni, Handbook of Experimental Pharmacology, 3rdEdn, Vallabh Prakashan, (1987) p. 175.

  • S. K. Kulkarni, Handbook of Experimental Pharmacology, 3rd Edn, Vallabh Prakashan, (1987) p. 131.


Abstract Views: 254

PDF Views: 0




  • Synthesis of N-Mannich Bases of some Substituted Carbazoles

Abstract Views: 254  |  PDF Views: 0

Authors

Neetu Verma
Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India
Shruti Awasthi
Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh, India
Vikrant Jain
Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India

Abstract


Through reactions with numerous secondary amines and a series of aldehydes, including formaldehyde and acetaldehyde, novel carbazole derivative conjugates were created from carbazole. Corresponding analogues were identified through spectral studies, and they were tested for their ability to reduce pain and control seizures using the Eddy's Hot Plate method and the maximum electrical shock convinced convulsion method, respectively. Students created the statistical analysis using the "t" test, and the standards were stated as mean SEM.

Keywords


Mannich bases, Carbazole, Anti-nociceptive, Anti-epileptic.

References