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Synthesis of N-Mannich Bases of some Substituted Carbazoles


Affiliations
1 Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India
2 Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh, India
     

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Through reactions with numerous secondary amines and a series of aldehydes, including formaldehyde and acetaldehyde, novel carbazole derivative conjugates were created from carbazole. Corresponding analogues were identified through spectral studies, and they were tested for their ability to reduce pain and control seizures using the Eddy's Hot Plate method and the maximum electrical shock convinced convulsion method, respectively. Students created the statistical analysis using the "t" test, and the standards were stated as mean SEM.

Keywords

Mannich bases, Carbazole, Anti-nociceptive, Anti-epileptic.
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  • Synthesis of N-Mannich Bases of some Substituted Carbazoles

Abstract Views: 275  |  PDF Views: 0

Authors

Neetu Verma
Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India
Shruti Awasthi
Department of Chemistry, Government College, Khurai - 470117, Madhya Pradesh, India
Vikrant Jain
Department of Chemistry, Faculty of Science and IT, Madhyanchal Professional University, Ratibad - 462044, Bhopal - Madhya Pradesh, India

Abstract


Through reactions with numerous secondary amines and a series of aldehydes, including formaldehyde and acetaldehyde, novel carbazole derivative conjugates were created from carbazole. Corresponding analogues were identified through spectral studies, and they were tested for their ability to reduce pain and control seizures using the Eddy's Hot Plate method and the maximum electrical shock convinced convulsion method, respectively. Students created the statistical analysis using the "t" test, and the standards were stated as mean SEM.

Keywords


Mannich bases, Carbazole, Anti-nociceptive, Anti-epileptic.

References