Formulation and Evaluation of Antioxidant Face Cream Containing Raspberry Fruit and Grape Seeds Extract

Antioxidant neutralizes free radicals, unstable oxygen molecules that break down skin cells and cause wrinkles, thus preventing impairment at the cellular level. In the present work, face cream formulations were prepared using antioxidant from natural source. Raspberry extract and Grape seed extract was used. Radical scavenging activity of raspberry, grape seeds was studied with standard ascorbic acid by DPPH method. Six cream base formulations were prepared and two formulations BF1 and BF4 were optimized. Six formulations of antioxidant cream were prepared using 2% extract. The various evaluation test like, pH, viscosity, grittiness, spreadability, skin irritation and antimicrobial test were carried out. The stability study over one week was also conducted. Raspberry and grapes seeds showed very good antioxidant activity with IC₅₀ value 0.033μg/ml and 0.072μg/ml respectively. Face cream formulation shown active zone of inhibition within range of 9-12 mm, indicating that, all the formulation have good preservation activity. The study was concluded with that, natural source for excipient is the more suitable due to easy availability, non-toxicity and biocompatible properties of excipient. After studying the physical parameters, stability study evaluation, it is concluded that the product has the best capacity to reduce free radical and can be used as the provision of a barrier to protect skin.