Research Journal of Topical and Cosmetic Sciences

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The Potentials of Dehydroepiandrosterone (DHEA) in Skin Ageing Process


Affiliations
1 University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, India
2 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, India
     

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Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.

Keywords

DHEA, Testosterone, Estrogen, Targeted Drug Delivery.
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  • The Potentials of Dehydroepiandrosterone (DHEA) in Skin Ageing Process

Abstract Views: 271  |  PDF Views: 1

Authors

Anshita Gupta
University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, India
Swarnlata Saraf
University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, India
Chanchal Deep Kaur
Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, India
Shailendra Saraf
University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, India

Abstract


Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.

Keywords


DHEA, Testosterone, Estrogen, Targeted Drug Delivery.