Research Journal of Topical and Cosmetic Sciences

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Transfersomes: A New Vesicular Carrier System in Topical Drug Delivery


Affiliations
1 Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India
     

   Subscribe/Renew Journal


Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive transcutaneous immunisation. Extremely deformable vesicles prepared by the judicious combination of several materials provide a solution to this problem: the resulting agent carriers, transfersomes, are the only tested colloidal system that can transport even large macromolecules spontaneously through the skin in immunologically active form. Transfersomes are applied in a non-occluded method to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. Transfersomes are made up of a phospholipids component along with a surfactant mixture. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. These drugs find place in different places in the elastic vesicle before they get delivered beneath the skin. Peripheral drug targeting, transdermal immunization can also be achieved with this type of drug delivery system. The Transfersomes are characterized for entrapment efficiency, Vesicle Diameter ,Vesicle size distribution and zeta potential, No. of vesicles per cubic mm ,Confocal scanning laser microscopy study ,Degree of deformability or permeability measurement ,Turbidity measurement Drug content : Surface charge and charge density, Penetration ability ,Occlusion effect, Physical stability, In-vitro drug release, Invitro Skin permeation Studies, etc. These carrier systems are preferred over other carrier systems, as these are biodegradable, biocompatable and nontoxic carrier with better potential for skin penetration and prolongation of drug release. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction protein, and albumin.

Keywords

Elastic Vesicles, Transfersomes, Permeation Flux, Stability Enhancer.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Sivannarayana P, Prameela Rani A, Saikishore V transferosomes: Ultra Deformable Vesicular Carrier Systems in Transdermal Drug Delivery System , Research J. Pharma. Dosage Forms and Tech. 2012; 4(5): 243-255340-343

  • Shailesh T. Prajapati, Charmi G. Patel and et.al . Transfersomes: A Vesicular Carrier System For Transdermal Drug Delivery, Asian Journal of Biochemical and Pharmaceutical Research Issue 2 (Vol. 1) 2011.

  • Jadupati Malakar , Suma Oomen Sen , Amit Kumar Naya . Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery, Saudi Pharmaceutical Journal (2012) 20, 355–363.

  • Transdermal immunisation with anintegral membrane component, gap junction protein, by means of ultradeformable drug carriers, transfersomes Paul.A, G.Cevc and Bachhawat F, Vaccine 1998 Volume 16 N 2/3.

  • Walve J.R, Bakliwal S.R, Rane B.R, Pawar S.P .transfersomes: a surrogated carrier for transdermal drug delivery system, International Journal of Applied Biology and Pharmaceutical Technology, ISSN 0976-4550.

  • Modi CD, Bharadia PD. Bechraji, et.al.Transfersomes: New Dominants for Transdermal Drug Delivery AJPTR. 2012; 2(3): 71-91

  • Sahil M. Gavali, Sharad S. Pacharane, Kisan R. Jadhav . Clinical P Transfersome: A New Technique For Transdermal Drug Delivery. IJRPC 2011, 1(3) Jadhav et al.,ISSN: 22312781

  • Patel R, Singh SK, Singh S,et.al . Development and Characterization of Curcumin Loaded Transfersome for Transdermal Delivery. J Pharm Sci Res 2009; 1(4):71-80.

  • Sheo Datta Maurya, Shweta Aggarwal, Vijay Kumar Tilak . Enhanced Transdermal delivery of indinavir sulfate via transfersomes. Pharmacie Globale (IJCP) 2010; 1(06):1-7.

  • Prajapati ST, Patel CG, Patel CN.Transfersomes: A Vesicular Carrier System for Transdermal Drug Delivery. Asian J Biochemical Pharma Res 2011; 1(2):507-524.

  • Berge vanden BAI and Wertz PW, Junginger HE and Bouwstra JA. Elasticity of Vesicles Assessed by Electron Spin Resonance.Electron Microscopy and Extrusion Measurement. Int J Pharm.2001;217:13–24.

  • Schatzlein A, Cevc G. Skin penetration by phospholipids vesicles, Transfersomes as visualized by means of the Confocal Scanning Laser Microscopy, in characterization, metabolism, and novel biological applications. Champaign. AOCS Press 1995; 191-209.

  • Planas M.E., Gonzalez.P, Rodriguez.L, et.al .Microencapsulation: Methods and Industrial Applications, Second Editio, Anesthesia and Analgesia., 1992,75, 615.

  • Hafer.c, Goble.r, Deering.p, et.al .Transferosome: an enhancement approach for transdermal drug delivery system. Anticancer Res., 1999, 19(2c), 1505.

  • Trotta.M, Peira.E, M. Gallarate et.al., Deformable liposomes as deposition and stability .International Journal of Pharmaceutics., 2004, 270, 119.

  • Maghraby,.E.I, Williams.G.M and B. W. Barry., Skin delivery of oestradiol from lipid vesicles: importance of liposome structure.International Journal of Pharmaceutics., 2000,204, 159.

  • Song Y.K and Kim C.K. Topical delivery of low-molecularweight heparin with surface-charged flexible liposomes. Biomaterials., 2006, 27, 271.

  • Oh Y.K , Kim M.Y, Shin J.Y and et.al., Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models,.Journal of Pharmacy and Pharmacology., 2006,58, 161.

  • Dubey.V, Mishra.D, Asthana.A and N. K. Jain. . Transdermal Delivery of a pineal Hormone: Melatonin via elastic liposome., Biomaterials; 2006, 27, 3491.

  • Transfersome., Cited on 12th April 2011, http//www.wikipedia/Transfersome '

  • Cevc.G, Blume.G and Schatzlein.A., Handbook of Non-Invasive Drug Delivery Systems: Science and Technology.Journal of Controlled Release., 1997, 45,211.

  • Benson H.A,Expert Opin Drug Deliv., Transfersomes for transdermal drug delivery 2006, 6, 727.

  • Xiao-Ying .L, Luo J.B, Yan Z.H, H. S. Rong and W. M. Huang., Preparation and in vitro evaluations of topically applied capsaicin transfersomes. Zhongguo Zhong Yao Za Zhi., 2006, 31(12), 981

  • Jalon, G.E. Ygartua, P., Santoyo, S., J Control Release. 2001, 75, 191-197

  • Chapman.s.J, and Walsh.A; Arch. Dermatol Res., 1998, 282, 304..

  • Hafer C, Goble R, Deering P,et.al., Formulation of interleukin-2 and interferon-alpha containing ultra deformable carriers for potential transdermal application, Anticancer Res., 1999; 19(2c):1505-7.


Abstract Views: 1180

PDF Views: 0




  • Transfersomes: A New Vesicular Carrier System in Topical Drug Delivery

Abstract Views: 1180  |  PDF Views: 0

Authors

A. Santosh Kumar
Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India
P. Kavya Deepika
Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India
D. Nagasen
Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India
D.V. Dakshina Murthy
Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India
V. Sai Kishore
Bapatla College of Pharmacy , Bapatla, Guntur dist. Andhra Pradesh, India

Abstract


Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive transcutaneous immunisation. Extremely deformable vesicles prepared by the judicious combination of several materials provide a solution to this problem: the resulting agent carriers, transfersomes, are the only tested colloidal system that can transport even large macromolecules spontaneously through the skin in immunologically active form. Transfersomes are applied in a non-occluded method to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. Transfersomes are made up of a phospholipids component along with a surfactant mixture. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. These drugs find place in different places in the elastic vesicle before they get delivered beneath the skin. Peripheral drug targeting, transdermal immunization can also be achieved with this type of drug delivery system. The Transfersomes are characterized for entrapment efficiency, Vesicle Diameter ,Vesicle size distribution and zeta potential, No. of vesicles per cubic mm ,Confocal scanning laser microscopy study ,Degree of deformability or permeability measurement ,Turbidity measurement Drug content : Surface charge and charge density, Penetration ability ,Occlusion effect, Physical stability, In-vitro drug release, Invitro Skin permeation Studies, etc. These carrier systems are preferred over other carrier systems, as these are biodegradable, biocompatable and nontoxic carrier with better potential for skin penetration and prolongation of drug release. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction protein, and albumin.

Keywords


Elastic Vesicles, Transfersomes, Permeation Flux, Stability Enhancer.

References