South Indian Journal of Biological Sciences

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Anti-Diarrhoeal Activity of Friedelin Isolated from Azima tetracantha Lam. in Wistar Rats


Affiliations
1 Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju 561-756, Korea, Republic of
2 Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box. 2455, Riyadh 11451, Saudi Arabia
3 Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600034, Tamil Nadu, India
 

The present study was aimed to evaluate the anti-diarrhoeal activity of friedelin isolated from leaves of Azima tetracantha Lam. The anti-diarrhoeal effect of friedelin was studied by using castor oil-induced diarrhoea, gastrointestinal motility test, magnesium sulphate-induced diarrhea and castor oil-induced enteropooling in rats. Friedelin (20 mg/kg) showed significant (P < 0.0001) reduction of intestinal transit and gastric emptying which were similar to the anti- motility activity as known compound atropine (0.1 mg/kg). Friedelin (20 mg/kg) also exerted significant anti-enteropooling effects, against castor oil-induced enteropooling in rats. The defaecation frequencies and the faecal droppings wetness were significantly (P < 0.0001) reduced. Additionally, friedelin (20 mg/kg) revealed significant (P < 0.0001) inhibition (89.64%) of castor oil-induced diarrhea. The overall results elucidated that the anti-diarrhoeal activity of friedelin may be due to its anti-secretory and anti-motility properties, which consequently provide evidence for the traditional claim.

Keywords

Diarrhoea, Enteropooling, Motility, Azima tetracantha, Friedelin, Castor Oil.
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  • Anti-Diarrhoeal Activity of Friedelin Isolated from Azima tetracantha Lam. in Wistar Rats

Abstract Views: 265  |  PDF Views: 5

Authors

Paulrayer Antonisamy
Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju 561-756, Korea, Republic of
Veeramuthu Duraipandiyan
Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box. 2455, Riyadh 11451, Saudi Arabia
Savarimuthu Ignacimuthu
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600034, Tamil Nadu, India
Jong-Hoon Kim
Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju 561-756, Korea, Republic of

Abstract


The present study was aimed to evaluate the anti-diarrhoeal activity of friedelin isolated from leaves of Azima tetracantha Lam. The anti-diarrhoeal effect of friedelin was studied by using castor oil-induced diarrhoea, gastrointestinal motility test, magnesium sulphate-induced diarrhea and castor oil-induced enteropooling in rats. Friedelin (20 mg/kg) showed significant (P < 0.0001) reduction of intestinal transit and gastric emptying which were similar to the anti- motility activity as known compound atropine (0.1 mg/kg). Friedelin (20 mg/kg) also exerted significant anti-enteropooling effects, against castor oil-induced enteropooling in rats. The defaecation frequencies and the faecal droppings wetness were significantly (P < 0.0001) reduced. Additionally, friedelin (20 mg/kg) revealed significant (P < 0.0001) inhibition (89.64%) of castor oil-induced diarrhea. The overall results elucidated that the anti-diarrhoeal activity of friedelin may be due to its anti-secretory and anti-motility properties, which consequently provide evidence for the traditional claim.

Keywords


Diarrhoea, Enteropooling, Motility, Azima tetracantha, Friedelin, Castor Oil.