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Anti-Diarrhoeal Activity of Friedelin Isolated from Azima tetracantha Lam. in Wistar Rats
The present study was aimed to evaluate the anti-diarrhoeal activity of friedelin isolated from leaves of Azima tetracantha Lam. The anti-diarrhoeal effect of friedelin was studied by using castor oil-induced diarrhoea, gastrointestinal motility test, magnesium sulphate-induced diarrhea and castor oil-induced enteropooling in rats. Friedelin (20 mg/kg) showed significant (P < 0.0001) reduction of intestinal transit and gastric emptying which were similar to the anti- motility activity as known compound atropine (0.1 mg/kg). Friedelin (20 mg/kg) also exerted significant anti-enteropooling effects, against castor oil-induced enteropooling in rats. The defaecation frequencies and the faecal droppings wetness were significantly (P < 0.0001) reduced. Additionally, friedelin (20 mg/kg) revealed significant (P < 0.0001) inhibition (89.64%) of castor oil-induced diarrhea. The overall results elucidated that the anti-diarrhoeal activity of friedelin may be due to its anti-secretory and anti-motility properties, which consequently provide evidence for the traditional claim.
Keywords
Diarrhoea, Enteropooling, Motility, Azima tetracantha, Friedelin, Castor Oil.
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