SMU Medical Journal

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Increasing carbapenem resistance led to difficulties in treatment of multidrug-resistant (MDR) A. baumannii infections. We aimed to investigate the carbapenemase genes in MDR A.baumanii isolates. A total of 80 MDR A. baumannii strains were studied by multiplex PCR with the hyplex® CarbOxa ID test system. It involves amplification of blaOXA-51-like, blaOXA-23- like, blaOXA-40-like and blaOXA-58-likegene families and hybridisation of the PCR products to specific oligonucleotide probes in an ELISA-based system.

All isolates were resistant against imipenem and meropenem while susceptible to colistin. The the intrinsic gene of A. baumannii was detected from 77 (96.25% ) strains. The presence of blaOXA 23-like, blaOXA 58-like and blaOXA 40-like genes were demonstrated in 48 (60%), 12 (15%), and 8 (10%) isolates, respectively. The blaOXA-23 - like was a common gene and colistin was a rare option for treatment of MDR A. baumannii infections in southeast of Turkey.


Keywords

MDR A. baumannii, Hyplex CarbOxa ID, blaOXA-23-like, blaOXA-40-like and blaOXA-58-like.
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