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New Method for Spectrophotometric Determination of Lidocaine
This work include prepration the organic reagent 3-hydroxy-4-[(4-hydroxyphenyl)azo]-1- naphthalenesulfonic acid by coupling diazonium of 1-amino-2-naphthol-4-sulfonic acid with phenol. The reagent react with Lidocaine in acidic medium( PH = 4) to produce red colored complex with mole ratio 1:1 (L:M) and maximum absorbance at 510 nm . this method show obey to beers in the range of 1.44 - 69.31 ppm, with molar absorptivity of 4.1633×103 L mole-1 cm-1 Sandell's sensitivity 0.0693 μg·cm-2 The effects of variables such as pH, time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations.
Keywords
Lidocaine, Determination, Spectrophotometry.
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- Hakim , O. M; El-Hag, Y. G; Haikal , M. A. (2005) J. Aapos . 9, 279-284.
- Yazici , F. G; A rslan, M; Birbicer , H; Kanik , A; Aban, M; Oral , U. (2003) Pain Clinic 15, 339-343.
- Edhorn, G. A; Pharx, M. (1971) Determination of lidocaine in whole blood by gas chromatography. Canad. Anaesth. Sot.. J. vol. 18, no. 2.
- Sporkert , F; Pragst , F.(2000) Determination of Lidocaine in Hair of Drug Fatalities by Headspace Solid-Phase Microextraction. Journal of Analytical Toxicology. Vol. 24, July/August.
- Janguo, L; Huangxia, J. (2006) Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis. 27, 3467–3474.
- Zonghui, Q; Guangming, S; Rong, T; Lijun, P. (2007) Determination of the Content of Lidocaine Hydrochloride in Different Medium by Spectrophotometric Method. China Pharmacy. 34.
- Sasa, I ; Dada, Y; Lnln, G. (1975) Spectrophotometric determination of lidocaine in some pharmaceutical preparations using bromocresol green. Pharmazie. 408. 30, 6, PMID 1161799.
- Putta, M; Gurupadayya, B. M; Disha, N. S; Sama, S.(2013) Spectrophotometric determination of lidocaine in bulk and pharmaceutical formulations. Pharm Analysis & Quality Assurance. 02 , 573.
- Qin, Z; Pu, L; Tan, R.(2007) Spectrophotometric Method for Determining Lidocaine Hydrochloride with Eosin Methylene Blue. Journal of Jiangxi Normal University. 03.
- Gung, B.W., Taylor, R.T.(2004) J. Chem. Ed., 81, 1630.
- Decelles, C. (1949), J. Chem. Ed., 26, 583.
- Yoe J.H., Jones A.L.(1944) Colorimetric Determination of Fe with disodium 1,2dihydroxybenzene-3,5-disulfonate; JOURNAL OF Journal of Industrial & Engineering Chemistry 16 (3): 14–19.
- Warren C., Vosburgh, Gerald R.(1941) Cooper. the Identification of Complex ions in Solution by Spectrophotometric measurements; Journal of the American Chemical Society 63 (2): 437-442.
- Miller JC, Miller JN. (1993) Statistics in Analytica Chemistry; 3rd ed., Ellis Horwood, Chichester, pp. 119.
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