SMU Medical Journal

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This work include prepration the organic reagent 3-hydroxy-4-[(4-hydroxyphenyl)azo]-1- naphthalenesulfonic acid by coupling diazonium of 1-amino-2-naphthol-4-sulfonic acid with phenol. The reagent react with Lidocaine in acidic medium( PH = 4) to produce red colored complex with mole ratio 1:1 (L:M) and maximum absorbance at 510 nm . this method show obey to beers in the range of 1.44 - 69.31 ppm, with molar absorptivity of 4.1633×103 L mole-1 cm-1 Sandell's sensitivity 0.0693 μg·cm-2 The effects of variables such as pH, time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations.

Keywords

Lidocaine, Determination, Spectrophotometry.
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