SMU Medical Journal

The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off


Problems: Search for new drugs of gastric ulcer. Experimental approach: Anti gastric ulcer activity of Amaranthus spinosus Linn. in aspirin induced gastric ulcers was studied in rats. Findings: Results showed that Amaranthus spinosus Linn. leaves significantly reduced ulcer index induced by aspirin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity. Elevated level of gastric pepsin during aspirin induced ulcers was found lowered by the leaves indicating its involvement in offensive mechanism in production of gastric ulcer. Leaves further increased gastric mucin which showed its gastric cytoprotective effect. The plant leaves prevented loss of gastric protein, DNA and the increased lipid peroxidation during ulceration by aspirin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug. Conclusion: Anti ulcerogenic activity of Amaranthus spinosus Linn. leaves was mediated through anti oxidant defense mechanism.

Keywords

Amaranthus spinosus Linn, Aspirin, Ranitidine, Gastric Ulcer, SOD, CAT, GSH.
User
Notifications
Font Size