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Percentage of T Cells in Diabetes Mellitus Patients Managed with Different Treatment Modalities


Affiliations
1 Department of Immunology, University of Health Sciences Lahore, Pakistan
2 Department of Biostatistics, University of Health Sciences Lahore, Pakistan
 

Diabetes mellitus (DM) is managed by insulin (type-I diabetes) and oral hypoglycemics (type-II diabetes). Oral hypoglycemics prevent T cell proliferation. It was hypothesiszed that oral hypoglycemics decreases number of T cells.

A cross sectional study was undertaken to determine frequency of T cells in DM patients being treated with oral hypoglycemics and with insulin. Study included 80 subjects and their blood sample was analyzed for T cells by four color FACS caliber, using fluorescein isothiocyanate tagged monoclonal antibodies against CD3 and PerCP against CD45.

Mean±SD of T cell percentage of patients on oral hypoglycemics was high (61.11±8.68 %) compared to insulin therapy (60.80±11.91 %). On comparison there was no statistically significant difference.

No significant difference in percentage of T cells but significant difference was observed in age, BMI, systolic and diastolic BP of DM patients on oral hypoglycemics and insulin therapy.


Keywords

T Cells, Diabetes Mellitus, Oral Hypoglycemics, Insulin.
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  • Percentage of T Cells in Diabetes Mellitus Patients Managed with Different Treatment Modalities

Abstract Views: 222  |  PDF Views: 118

Authors

Rabia Tufai
Department of Immunology, University of Health Sciences Lahore, Pakistan
Nadeem Afzal
Department of Immunology, University of Health Sciences Lahore, Pakistan
Khursheed Javeid
Department of Immunology, University of Health Sciences Lahore, Pakistan
Faheem Shahzad
Department of Immunology, University of Health Sciences Lahore, Pakistan
Saba Khaliq
Department of Immunology, University of Health Sciences Lahore, Pakistan
Afia Abbas
Department of Immunology, University of Health Sciences Lahore, Pakistan
Waqas Latif
Department of Biostatistics, University of Health Sciences Lahore, Pakistan
Romeeza Tahir
Department of Immunology, University of Health Sciences Lahore, Pakistan

Abstract


Diabetes mellitus (DM) is managed by insulin (type-I diabetes) and oral hypoglycemics (type-II diabetes). Oral hypoglycemics prevent T cell proliferation. It was hypothesiszed that oral hypoglycemics decreases number of T cells.

A cross sectional study was undertaken to determine frequency of T cells in DM patients being treated with oral hypoglycemics and with insulin. Study included 80 subjects and their blood sample was analyzed for T cells by four color FACS caliber, using fluorescein isothiocyanate tagged monoclonal antibodies against CD3 and PerCP against CD45.

Mean±SD of T cell percentage of patients on oral hypoglycemics was high (61.11±8.68 %) compared to insulin therapy (60.80±11.91 %). On comparison there was no statistically significant difference.

No significant difference in percentage of T cells but significant difference was observed in age, BMI, systolic and diastolic BP of DM patients on oral hypoglycemics and insulin therapy.


Keywords


T Cells, Diabetes Mellitus, Oral Hypoglycemics, Insulin.