SMU Medical Journal

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1-Butyl-3-methylimidazolium based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of N-benzyl-fluoro nitrone derived in situ from 2,6- difluoro benzaldehyde and N-benzylhydroxylamine, with activated alkenes and electron deficient alkynes to afford enhanced rates and improved yields of isoxazolidine, isoxazolines. All the novel isoxazolidine and isoxazoline derivatives have been screened for antimicrobial activities and found to be very active.

Keywords

N-Benzyl Fluoro Nitrone, Cycloaddition Reaction, Fluoro Isoxazolidine & isoxazolines, Ionic Liquid, 1,3-amino Alcohol, Aldehyde/ketone Synthesis, Antimicrobial Activity.
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