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Therapeutic Uses of Epicatechin in Diabetes and Cancer


Affiliations
1 Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
2 Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
3 Department of Chemistry, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
 

Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while is anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which is diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on human while understanding the potential mechanisms of these aforementioned effects.

Keywords

Angiogenesis, Carcinoma, Diabetes Mellitus, Epicatechin, Oxidative Stress.
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  • Therapeutic Uses of Epicatechin in Diabetes and Cancer

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Authors

Layth Abdulmajeed Abdulkhaleq
Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
Mohammed Abdulrazzaq Assi
Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
Mohd Hezmee Mohd Noor
Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
Rasedee Abdullah
Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
Mohd Zamri Saad
Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia
Yun Hin Taufiq-Yap
Department of Chemistry, Universiti Putra Malaysia, Serdang-43400, Selangor, Malaysia

Abstract


Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while is anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which is diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on human while understanding the potential mechanisms of these aforementioned effects.

Keywords


Angiogenesis, Carcinoma, Diabetes Mellitus, Epicatechin, Oxidative Stress.