![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
Study of Antihyperglycemic, Antihyperlipidemic and Nephroprotective Activity of Cassia auriculata L. Extract in Streptozotocin Induced Diabetic Rats.
Present study was carried out to investigate antihyperglycemic, antihyperlipidemic and nephroprotective activity of hydroalcoholic extract of aerial parts of Cassia auriculata L. (HACA) in streptozotocin induced diabetes rats, to focus on its possible mode of action and identification of possible phytoconstituents responsible for the proposed activity.
Experimental diabetes was induced in wistar rats by single intraperitonial injection of streptozotocin (65 mg/kg). Animals were divided in six groups (n=6) and treated with variable doses of HACA for 4 weeks. At the end of 4 weeks, fasting blood glucose, oral glucose tolerance test (OGTT), blood urea nitrogen (BUN), serum creatinine, serum total proteins, serum albumin, lipid profile, glycosylated haemoglobin, was determined. Antioxidant enzymes of kidney were evaluated. Urine was analyzed for albumin, total proteins and creatinine clearance. Kidney of experimental animals was examined to determine structural changes. The results of our study demonstrate antihyperglycemic, antihyperlipidemic and nephroprotective potential of aerial parts of Cassia auriculata L. justifying its use in the indigenous system of medicine.
Keywords
- Clinical Medicine, 5th ed., Ed. WB Saunder, London 2002.
- V.S. Patel, V. Chitra, P.L. Prasanna and V. Krishnaraju, “Hypoglycemic effect of aqueous extract of Parthenium hysterophorous L. in normal and alloxan induced diabetic rats,” Indian J. Pharmacol., vol.. 40, pp. 183-185, 2008.
- G. Chandramohan, S. Ignacimuthu and K.V. Pugalendi. “A novel compound from Casearia esculenta (Roxb.) ischolar_main and its effect on carbohydrate metabolism in streptozotocin diabetic rats.” Eur J Pharmacol, vol.590, pp.437- 443, 2008.
- J. Wadekar, R. Sawant and B. Honde, “Anthelmintic and Antibacterial Potential of Cassia auriculata Roots,” Inter J Pharma Res, vol. 1, pp. 93-98, 2011.
- M. Shiradkar, G. Pawankumar and K. Shah, “Pharmacological evaluation of Cassia auriculata bark extract,” Inter J Pharma Bio Sci, vol.2, pp. 758-766, 2011.
- J. Rajeswari, K. Kesava and B. Jayakar. “Antidiabetic activity and chemical characterization of aqueous/ ethanol prop ischolar_mains extracts of Pandanus fascicularis Lam in streptozotocin induced diabetic rats,” Asian Paci J Trop Biomed, vol. 10, pp. 170-174, 2012.
- A. Shirwaikar, K. Rajendran and I.S. Punitha, “Antidiabetic activity of alcoholic stem extract of Coscinium Fenestratum in streptozotocinnicotinamide induced type 2 diabetic rats,” J Ethnopharmacol, vol. 97, pp. 369-374, 2005.
- S. Gupta, S. B. Sharma, S. K. Bansal and K. M. Prabhu, “Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes” J Ethnopharmacol vol. 123, pp. 499-503, 2009.
- P. Vijayaraj, K. Muthukumar, J. Sabariraja and V. Nachiappan, “Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats,” Ex Toxicol Pathol., vol. 4, pp.736-748, 2011.
- D. P. Uma, S. Selvi, S. Selvam and P. Chnnaswamy, “Antidiabetic and hypoglycemic effect of Cassia auriculata in alloxan induced diabetic rats,” Inter J Pharmacol, vol. 2, pp. 601-607, 2006.
- A. Kalaivani, A. Umamaheswari, A. Vinayagam and K. Kalaivani, “Antihyperglycemic and antioxidant properties of Cassia auriculata leaves and flowers on alloxan induced diabetic rats,” Pharmacology online, vol. 1, pp. 204-217, 2008.
- K. R. Khandelwal, Practical Pharmacognosy, 6th ed., Ed. Nirali Prakashan, India 2006.
- A.R. Juvekar and D.D Bandawane, “Preliminary study on hypoglycemic effect of Alstonia scolaris Linn. in normal and streptozotocin induced diabetic rats,” Adv Pharmacol Toxicol, vol.10, pp. 89-92, 2009.
- H. Yankunzo, Q.U. Ahmed and N.A. Talib, “Beneficial effect of the leaves of Murraya koeniggi (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo,” J Ethnopharmacol., vol. 135, pp. 88-94, 2010.
- D.D. Bandawane, K.H. Bibave and U.S. Patil, “Antihyerglycemic and antihyperlipidemic effects of methanolic extract of Holarrhena antidysentrica bark in alloxan induced diabetes mellitus in rats,” Pharmacologia, vol. 4, pp. 95-106, 2013.
- W.T. Friedewald, R.I. Levy and D.S. Fradrickson, “Estimation of concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge,” Clin Chem, vol. 18, pp. 499-502, 1972.
- G. Kaur, J. Zoobi and A. Mohammad, “ Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice,” Food Chem Toxicol, vol. 44, pp. 984-993, 2006.
- S. Kumar and V. Prakash. “Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves on alloxan induced diabetic rats,” Asian Pac J Trop Med , pp. 347-352, 2011.
- S. Sahreen, M.R. Khan and R.A. Khan. “Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4 induced damage in rat,” Complement Alter Medi, vol. 11, pp. 1-10, 2011.
- S.L. Marklund, Handbook of methods for oxygen radical research. 2nd ed. Ed CRC Press, London, 1985.
- S. Siddiqui, M.R Khan and W.A., Siddiqui , “Comparative hypoglycemic and nephroprotective effects of tocotrienol rich fraction (TRF) from palm oil and rice bran oil against hyperglycemia induced nephropathy in type 1 diabetic rats,” ChemicoBiological Inter, vol. 188, pp. 651-658, 2010.
- F. Giacco and M. Brownlee, “Oxidative stress and diabetic complications,” Circ Res, vol. 107, pp. 1058-1070, 2010.
- S.H. Lee, Y.S. Kim, S.J. Lee and B.C. Lee. “The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy,” J Ethnopharmacol,, vol. 137, pp. 1409-1414, 2011.
- P.S. Shajeela, V. Kalpanadevi and V.R. Mohan, “Potential antidiabetic, hypolipidemic and antioxidant effects of Xanthosoma Sagittifolium extract in alloxan induced diabetic rats,” Int J Pharm Pharm Sci, vol. 5, pp. 27-31, 2013.
- P. Jha, B.K. Das and N. Baral, “Glycemic status, lipid profile and protenuria in diabetic nephropathy,” J Nepal Med Assoc, vol.49, pp. 143-146, 2010.
- R.F. Rosario and S. Prabhakar, “Lipids and diabetic nephropathy,” Curr Diabetes Rep, vol. 6, pp. 455462, 2006.
- X. Wen, Y. Zheng and X. Jia, “Zhenqing recipe alleviates diabetic nephropathy in type 2 diabetic rats through suppression of SREBP-1c,” J Ethnopharmacol, vol. 142, pp. 144-150, 2012.
- R.K. Gupta, D. Kumarand and R. Singh, “Antidiabetic activity of Passiflora incarnata Linn in streptozotocin induced diabetes in mice,” J Ethnopharmacol, vol. 139, pp. 801-806, 2012.
- N.R. Loon, “Diabetic kidney disease: preventing dialysis and transplantation,” Clin Diabetes, vol. 21, pp.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 138
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 93