Indian Journal of Drugs and Diseases

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Carbohydrate Metabolism Modulating Effect of Withania somnifera in Hepatocellular Carcinoma


Affiliations
1 Department of Medical Biochemistry, University of Madras, Tharamani, Chennai, India
 

Hepatocellular carcinoma is the third leading cause for cancer related death worldwide. Cancer cells exhibit a common set of functional characteristics, i.e. they consume a larger amount of glucose, maintain a much higher rate of glycolysis and convert a majority of glucose into lactic acid even in the presence of oxygen compared to that of normal cells. The high of lactate content in cancer cells (Warburg effect) favors their growth and invasion. The tumor cells preferentially use glycolysis over mitochondrial oxidative phosphorylation for glucose-dependent ATP production. This deviant energetic metabolism is a potential hallmark of cancer cells and has been thought to be the ischolar_main of tumor formation and growth. In the present study, efficacy of methanolic extract of Withania sominfera in carbohydrate metabolism modulating activity is studied in DEN induced hepatocellular carcinoma.

Keywords

Hepatocellular Carcinoma, Withania sominfera, N-notrosodiethylamine (DEN), Carbohydrate Metabolism, Warburg Effect
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  • Carbohydrate Metabolism Modulating Effect of Withania somnifera in Hepatocellular Carcinoma

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Authors

Deepa Babu
Department of Medical Biochemistry, University of Madras, Tharamani, Chennai, India
N. Rajaeswari
Department of Medical Biochemistry, University of Madras, Tharamani, Chennai, India

Abstract


Hepatocellular carcinoma is the third leading cause for cancer related death worldwide. Cancer cells exhibit a common set of functional characteristics, i.e. they consume a larger amount of glucose, maintain a much higher rate of glycolysis and convert a majority of glucose into lactic acid even in the presence of oxygen compared to that of normal cells. The high of lactate content in cancer cells (Warburg effect) favors their growth and invasion. The tumor cells preferentially use glycolysis over mitochondrial oxidative phosphorylation for glucose-dependent ATP production. This deviant energetic metabolism is a potential hallmark of cancer cells and has been thought to be the ischolar_main of tumor formation and growth. In the present study, efficacy of methanolic extract of Withania sominfera in carbohydrate metabolism modulating activity is studied in DEN induced hepatocellular carcinoma.

Keywords


Hepatocellular Carcinoma, Withania sominfera, N-notrosodiethylamine (DEN), Carbohydrate Metabolism, Warburg Effect

References