Indian Journal of Drugs and Diseases

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This study was aimed at comparing the antidiabetic and antihyperlipidemic activities of various doses (100,150, 200mg/kg body weight) of crude ethanol extract of Bryophyllum pinnatum and Glibenclamide (a reference drug). Thirty adult male rats (Wistar strain) weighing between 170-200g were used in this study. After 14 days of treatment, the rats were sacrificed and blood collected from the jugular vein was analysed accordingly. Results obtained showed that there were no significant differences (PBryophyllum pinnatum and the reference drug in serum glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL) levels. All doses of the extract of Bryophyllum pinnatum and the reference drug increased the levels of high-density lipoprotein cholesterol (HDL) but the increase were not significant (PBryophyllum pinnatum. Extracts of Bryophyllum pinnatum may thus help in the management of diabetes mellitus and its related complications.

Keywords

Diabetes Mellitus, Alloxan, Bryophyllum pinnatum, Lipid Profile and Atherogenic Index
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