Indian Journal of Drugs and Diseases

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Glycowithanolides (WSG) is the extract of Withania somnifera leaves was tested to find its effect on fucose content in salivary glands of D-galactose(Dg) stressed adult and old male mice (Mus musculus). Adult and old male mice were divided in to protective group and curative group. Both the groups were further divided into four batches viz. 1st is the control batch received 0.5 ml 0.9 % saline per day for 20 and 40 days for protective and curative group respectively. Mice from 2nd, 3rd and 4th batches of protective group received 0.5 ml D-galactose (Dg), Dg+ centrophenoxine(CPH) and D-galactose (Dg) + (WSG) respectively for 20 days. Mice from 2nd, 3rd and 4th batches of curative group received 0.5 ml D-galactose (Dg) for 20 days then followed by 0.5ml saline, centrophenoxine and WSG for further 20 days respectively. Fucose content (μg/mg proteins) in salivary glands was estimated. In D-galactose stressed adult and old mice it was decreased significantly, but restored by the treatment of WSG and centrophenoxine. The restoration was not exactly up to the normal level but was near to the normal level in adult. In D-galactose stressed old mice there was restoration in fucose content but it was not like that of adult. Restoration was significantly higher in WSG treatment. Thus WSG can be used as a powerful natural antistresser.

Keywords

Antioxidants, D-galactose, Fucose, Glycowithanolides, Salivary Glands
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