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A Robust Clinical Information on King of Carotenoids: a Systematic Review of the Literature


Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095,Tamilnadu, India
2 Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India
 

Astaxanthin is a red carotenoid pigment extensively found in living organisms. Though Astaxanthin is a carotenoid compound, unlike β-carotene (a vitamin A precursor), cannot be converted to vitamin A. Astaxanthin, a potent antioxidant,with other biological effects protects cell membranes from harmful damage in the body. Studies suggest Astaxanthin may be effective in treating diseases, including cardiovascular, immune disorders, tumor, diabetes, neurodegenerative conditions and inflammatory conditions. Recent studies on Astaxanthin have shown enhancing immune response and decreasing DNA damage in humans. Astaxanthin is capable of crossing the blood-brain barrier in mammals.

Keywords

Astaxanthin, Antioxidant, Immune Response
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  • Aoi W, Naito Y, Takanami Y, Ishii T, Akagiri S, Kato Y, Osawa T and Yoshikawa T (2008). Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem. Biophys. Res. Commun. 366(4),892-7. Epub 2007 Dec 17.
  • Fassett RG, Coombes JS (2009) Astaxanthin, Oxidative stress, inflammation and cardiovascular disease. Future Cardiol. 5(4), 333-342.
  • Ikeuchi M, Koyama T, Takahashi J and Yazawa K (2006) Effects of Astaxanthin supplementation on exercise-induced fatigue in mice. Biol. Pharm. Bull. 29(10), 2106-10.
  • Ikeuchi M, Koyama T, Takahashi J and Yazawa K (2007) Effects of Astaxanthin in obese mice fed a high-fat diet. Biosci .Biochem. 71 (4), 893-9. Epub 2007 Apr 7.
  • Iwasaki and Tawara (2006) Effects of Astaxanthin on eyestrain induced by accommodative dysfunction. J.Eye (Atarashi Ganka) (6),829-834.
  • Jyonouchi H et al.(2000) Antitumor activity of Astaxanthin and its mode of action. Nutr. Cancer.36(1),59-65.
  • Miki W (1991) Biological functions and activities of animal carotenoids. Pure Appl. Chem. 63:141.
  • Miyawaki et al., (2005) Effects of Astaxanthin on human blood rheology. J.Clin. Therap. Med. 21(4),421-429.
  • Nagaki et al.(2005) The effect of Astaxanthin on retinal capillary blood flow in normal volanteers. J.Clin. Opthal.28(5),537-542.
  • Nagaki et al., (2006) The supplementation effect of Astaxanthin on accommodative and asthennopia. J. Clin.Therap.Me.22(1),41-54.
  • Nagaki Y et al., (2002) Effects of Astaxanthin on accommodation, critical flicker fusions, and pattern evoked potential in visual disply terminal workers. J.Trad. Med. 19(5), 170-173.
  • Naguib YM (2000) Antioxidant activities of Astaxanthin and related carotenoids. J. Agric. Food Chem. 48(4),1150-1154.
  • Nakamura et al.(2004) Changes in visual function following peroral Astaxanthin. Japan J. Clin.Ophtal. 58(6),1051-1054.
  • Nitta et al. (2005) Effects of Astaxanthin on accommodation and asthenopia –dose finding study in healthy volenteers.J.Clin.Therap. Med.21(6),637- 650.
  • Ohgami et al.(2003) Effects of Astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest. Opthal. Vis. Sci.44 (6), 2694-2701.
  • Sawaki K et al. (2002) Sports performance benefits from taking natural Astaxanthin characterized by visual activity and muscle fatigue improvements in humans. J. Clin. Ther. Med. 18(9), 73-88.
  • Shiratori et al. (2005) Effect of Astaxanthin on accommodation and asthenopia- Efficancy identification study in healthy volunteers. J.Clin.Therap.Med. 21 (5), 543- 556.
  • Suzuki et al., (2006) Suppressive effects of Astaxanthin against rat endotoxin –induced uveitis by inhibiting the NF-kB signalling pathway.Exp.Eye Res.82,275-281.
  • Takahashi and Kajita(2005) Effects of Astaxanthin on accommodative recovery. J.Clin.Therap. Med. 21(4),431-436.
  • Terao J (1989) Antioxidant activity of betacarotene and related carotenoids in solution. Lipids .24:659.
  • Tso MO and Lam TT (1996) Method of retarding and ameliorating central nervous system and eye damage. US Patent 5,527,533.
  • Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H and Tada N (2009). Administration of natural Astaxanthin increases serum HDL-cholesterol and (2):520-523. Epub 2009 Oct 14.

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  • A Robust Clinical Information on King of Carotenoids: a Systematic Review of the Literature

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Authors

J. Balasubramanian
Shield Health Care Pvt Ltd, Chennai-600095,Tamilnadu, India
N. Narayanan
Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India
K. Shahul Hammed Maraicar
Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India
M. Murugan
Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India
K. Azhagesh Raj
Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India
M. Aruna
Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, India

Abstract


Astaxanthin is a red carotenoid pigment extensively found in living organisms. Though Astaxanthin is a carotenoid compound, unlike β-carotene (a vitamin A precursor), cannot be converted to vitamin A. Astaxanthin, a potent antioxidant,with other biological effects protects cell membranes from harmful damage in the body. Studies suggest Astaxanthin may be effective in treating diseases, including cardiovascular, immune disorders, tumor, diabetes, neurodegenerative conditions and inflammatory conditions. Recent studies on Astaxanthin have shown enhancing immune response and decreasing DNA damage in humans. Astaxanthin is capable of crossing the blood-brain barrier in mammals.

Keywords


Astaxanthin, Antioxidant, Immune Response

References