Indian Journal of Drugs and Diseases

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Studies on the Antiplasmodial Effects of Metaprim and Alaxin on some Selected Supplements


Affiliations
1 Department of Nutrition and Dietetics, Imo State Polytechnic, Umuagwo, Imo State, Nigeria
2 Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
 

Malaria is one of the most serious health challenges facing the world today. It is a disease caused by plasmodium. Successful malarial control depends greatly on treatment with effective anti-malarial drugs. Countries have implemented many national malarial treatment policy, which specifies drugs for treatment of both uncomplicated and severe malaria in pregnancy and what to do if first line treatment fails. This investigation is based on the antiplasmodial effects of Metaprim and Alaxin on some selected supplements such as grape juice, orange juice, supermalt and vitamin C. 80 patients (adults) infected with malaria parasites were chosen for this study. After which the anti-malarial drugs and the supplements were co-administered appropriately for 3 days. The result shows that the concomitant administration of the drugs with the multivitamin (super-malt) did not alter the efficacy and potency of the drugs, while grape juice, orange juice and vitamin C altered the efficacy and potency of the drugs. Therefore, the concomitant administration of these anti-malarial drugs with grape juice, orange juice and vitamin C as supplements should be avoided during the period of malaria treatment for the efficacy of drugs.

Keywords

Antiplasmodial ,Alaxin, Metaprim, Plasmodium, Supplements
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  • Adesokan AA and Akanji MA (2010) Antimalarial bioactivity of enantia chlorantha stem bark. Medical Plants: Phytochemistry Pharmaco.Therapeut. 4(1), 441-447.

  • Ajaiyeoba E, Falade M, Ogbole O, Okpako L and Akinboye D (2006) In vivo antimalarial and cytotoxic properties of Annona senegalensis extract. Afr. J. Tradit. Complement. Altern. Med. 3(1): 137–141.

  • Basu SK, Thomas JE and Acharya SN (2007) Prospects for growth in global nutraceutical and functional food markets: A Canadian perspective. Aust. J. Basic Appl. Sci. 1(4),637- 649.

  • Bledsoe G (2005) Malaria primer for clinicians in the United States. South Med.J. 98,1197-204.

  • Christopher JL Murray, Lisa C Rosenfeld, Stephen S Lim, Kathryn G Andrews, Kyle J Foreman, Diana Haring, Nancy Fullman, Mohsen Naghavi, Rafael Lozano and Alan D Lopez(2012) Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet. 379(9814),413–431.

  • Fong YL, Cadigan FC and Coatney GR (1971) A presumptive case of naturally occurring Plasmodium knowlesi malaria in man in Malaysia. Trans. R. Soc. Trop. Med. Hyg. 65(6),839–40.

  • Iyiola OA, Tijani AY and Lateef KM (2011) Antimalarial activity of ethanolic stem bark extract of Alstonia boonei in Mice. Asian J. Biological Sciences. 4,235-243.

  • Kilama W and Ntoumi F ( 2009 Malaria: a research agenda for the eradication era. Lancet. 374(9700),1480–1482.

  • Makarchikov AF, Lakaye B, Gulyai E, Czerniecki J, Coumans B, Wins P, Grisar T and Bettendorff L (2003) Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell. Mol. Life Sci. 60(7), 1477–1488.

  • Mohan RM, Choate JK, Golding S, Herring N, Casadei B and Paterson DJ (2000) Peripheral pre-synaptic pathway reduces the heart rate response to sympathetic activation following exercise training: role of NO. Cardiovasc. Res.47, 90–98.

  • Owira PM and Ojewole JA (2010) The grapefruit: an old wine in a new glass? metabolic and cardiovascular perspectives. Cardiovascu.J.Afri. 23,2-7

  • Singh B, Kim Sung L and Matusop A ( 2004) A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet. 363(9414),1017–1024.

  • Snow RW, Guerra CA, Noor AM, Myint HY and Hay SI (2005) The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature. 434(7030), 214–217.

  • Stump AL (2006) Management of grapefruitdrug interactions. Amer. Fam. Physician J. 12: 45-52

  • Sutherland CJ, Tanomsing N, Nolder D, et al. (2010) Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J. Infect. Dis. 201(10), 1544–1550.

  • Talman A, Domarle O, Mickenzie F, Ariey F and Robert V (2004) Gametocytogenesis: the puberty of Plasmodium falciparum. Malar.J. 3,247.

  • World Health Organization (2011) World Malaria Report: Summary and key points. 13 December 2011.http://www.malariavaccine.org/files/W MR-2011-summary.pdf


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  • Studies on the Antiplasmodial Effects of Metaprim and Alaxin on some Selected Supplements

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Authors

O. C. Adumanya
Department of Nutrition and Dietetics, Imo State Polytechnic, Umuagwo, Imo State, Nigeria
O. B. Odeghe
Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
A. A. Uwakwe
Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
F. C. Onwuka
Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
E. C. Ebiringa
Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria

Abstract


Malaria is one of the most serious health challenges facing the world today. It is a disease caused by plasmodium. Successful malarial control depends greatly on treatment with effective anti-malarial drugs. Countries have implemented many national malarial treatment policy, which specifies drugs for treatment of both uncomplicated and severe malaria in pregnancy and what to do if first line treatment fails. This investigation is based on the antiplasmodial effects of Metaprim and Alaxin on some selected supplements such as grape juice, orange juice, supermalt and vitamin C. 80 patients (adults) infected with malaria parasites were chosen for this study. After which the anti-malarial drugs and the supplements were co-administered appropriately for 3 days. The result shows that the concomitant administration of the drugs with the multivitamin (super-malt) did not alter the efficacy and potency of the drugs, while grape juice, orange juice and vitamin C altered the efficacy and potency of the drugs. Therefore, the concomitant administration of these anti-malarial drugs with grape juice, orange juice and vitamin C as supplements should be avoided during the period of malaria treatment for the efficacy of drugs.

Keywords


Antiplasmodial ,Alaxin, Metaprim, Plasmodium, Supplements

References